2012 Fiscal Year Final Research Report
Elucidation of the molecular mechanism of acute stress by visualization of dendritic spines in the hippocampus.
| Project/Area Number |
23700369
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Neuroscience in general
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| Research Institution | The University of Tokyo |
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Principal Investigator |
HOJO Yasushi 東京大学, 総合文化研究科, 特任研究員 (20536875)
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| Project Period (FY) |
2011 – 2012
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| Keywords | 海馬 / 記憶学習 / 急性ストレス / シナプス / スパイン / ストレスホルモン / コルチコステロン |
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| Research Abstract |
(1) We revealed that the molecular mechanism of spinogenesis induced by acute stress is“CORT→GR→Erk MAPK, PKA, PKC, PI3K→actin polymerization or rearrangement →spinogenesis and enlargement of spine head diameter”, which is completely different fromchronic stress effect with gene transcription.(2) We determined the concentration of hippocampus-synthesized CORT as 7 nM by using adrenalectomized rats and liquid chromatography- tandem mass spectrometry. Surprisingly, low dose CORT (~10 nM) induced spinogenesis, suggesting that low dose CORT may have a neurotrophic effect whereas high dose CORT (~1 μM) under stressful condition has deleterious effects.
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[Journal Article] Hippocampal synthesis of sex steroids and corticosteroids: essential for modulation of synaptic plasticity2011
Author(s)
Hojo Y, Higo S, Kawato S, Hatanaka Y, Ooishi Y, Murakami G, Ishii H, Komatsuzaki Y, Ogiue-Ikeda M, Mukai H, Kimoto T
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Journal Title
Front Neuroendocrine Sci
Volume: Article 43
DOI
Peer Reviewed
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[Journal Article] Endogenous Synthesis of Corticosteroids in the Hippocampus2011
Author(s)
Higo S, Hojo Y, Ishii H, Komatsuzaki Y, Ooishi Y, Murakami G, Mukai H, Yamazaki T, Nakahara D, Anna B, Kimoto T, Kawato S
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Journal Title
PLoS ONE
Volume: 6(7)
Pages: e21631
DOI
Peer Reviewed
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