2012 Fiscal Year Final Research Report
Adenosine A1 receptor interacts with mGluR1 and regulates motor learning
| Project/Area Number |
23700390
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
|
| Allocation Type | Multi-year Fund |
|---|
| Research Field |
Neuroscience in general
|
|---|
| Research Institution | Juntendo University |
|---|
Principal Investigator |
|
|---|
| Project Period (FY) |
2011 – 2012
|
| Keywords | G タンパク質共役型受容体 / シナプス可塑性 / 小脳長期抑圧 / 代謝型グルタミン酸受容体 |
|---|
| Research Abstract |
In various cell types, G protein-coupled receptors (GPCRs) form heteromeric complexes and cooperatively mediate the intrigue cellular responses.Although heteromeric GPCR complexes are suggested to occur in many neurons, their contribution to neuronal function remains unclear. We address this question using two GPCRs expressed in cerebellar Purkinje cells: adenosine A1 receptor, which regulates neurotransmitter release and neuronal excitability in central neurons and type -1 metabotropic glutamate receptor, which mediates cerebellar long-term depression, a form of synaptic plasticity crucial for cerebellar motor learning.
|
-
-
-
-
-
[Journal Article] Laminin a1 is essential for mouse cerebellar development2012
Author(s)
Ichikawa-Tomikawa N, Ogawa J, Douet V, Xu1 Z, Kamikubo Y, Sakurai T, Kohsaka S, Chiba H, Hattori N, Yamada Y, and Arikawa-Hirasawa E
-
Journal Title
Matrix Biology
Volume: 31
Pages: 17-28
DOI
Peer Reviewed
-
-
-
-
-
