2012 Fiscal Year Final Research Report
The role of FGF signal in brain development
| Project/Area Number |
23700410
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Nerve anatomy/Neuropathology
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| Research Institution | Chiba University |
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Principal Investigator |
SATO Tatsuya 千葉大学, 大学院・医学研究院, 助教 (00568222)
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| Project Period (FY) |
2011 – 2012
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| Keywords | 神経発生 / 形態形成 / 神経回路形成 |
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| Research Abstract |
It was shown that the combination of in vivo electroporation andthe newest version of the tetracycline (Tet)-controlled gene regulatory (Tet-On) systemefficiently can induce gene expression in various types of neurons such as cerebralpyramidal neurons in mouse embryonic and postnatal tissues. Fate map analysis showedthat the Fgf8-expressing cells differentiate into the cerebellum. The marked cells aredetected in more posterior and lateral part of the cerebellum when the Fgf8-expressingcells are marked in earlier developmental stage.
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