2014 Fiscal Year Final Research Report
Pathological relation between retinal degeneration and modulation of transthyretin expression by amyloid precursor protein
| Project/Area Number |
23700427
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Nerve anatomy/Neuropathology
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| Research Institution | Jikei University School of Medicine |
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Principal Investigator |
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| Project Period (FY) |
2011-04-28 – 2015-03-31
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| Keywords | 脊髄小脳失調症 / アルツハイマー病 / 網膜変性 |
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| Outline of Final Research Achievements |
Spinocerebellar ataxia 7 (SCA7) is an autosomal dominant neurodegenerative disorder characterized by cerebellar ataxia and retinal degeneration. SCA7, Alzheimer’s disease model and normal control mice were examined to elucidate mechanisms of retinal degeneration. In the photoreceptor and ganglion cells of SCA7, nuclear spliceosome altered its structure; these indicated that alteration of RNA metabolism might relate to retinal pathology of SCA7. Aggregation of amyloid precursor related proteins was observed in Alzheimer’s disease model mice. These novel findings will contribute to analyze pathogenesis of retinal degeneration in neurodegenerative disorders.
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| Free Research Field |
神経病理学
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