2013 Fiscal Year Final Research Report
Molecular mechanism of memory impairment in Alzheimer's disease mice model
Project/Area Number |
23700429
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Multi-year Fund |
Research Field |
Nerve anatomy/Neuropathology
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Research Institution | Saitama Medical University (2012-2013) The Institute of Physical and Chemical Research (2011) |
Principal Investigator |
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Project Period (FY) |
2011 – 2013
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Keywords | アルツハイマー病 / タウ / 長期抑制 / 新規モデル |
Research Abstract |
In this study, I focused on tau protein, which is related to tauopathy including Alzheimer's disease. Especially, tau phosphorylation is thought to relate to onset of neurodegenerative disease, I established a new mice model with accelerated phosphorylation of tau. Moreover, recent studies suggest the presence of tau in synaptic region. I focused on a receptor-related synaptic protein and suggested a new mechanism on the regulation of receptor trafficking.
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Research Products
(10 results)
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[Journal Article] Localization of mature neprilysin in lipid rafts2012
Author(s)
Kimihiko Sato, Chiaki Tanabe, Yoji Yonemura, Haruhiko Watahiki, Yimeng Zhao, Sosuke Yagishita, Maiko Ebina, Satoshi Suo, Eugene Futai, Masayuki Murata, Shoichi Ishiura
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Journal Title
J. Neurosci. Res.
Volume: 90(4)
Pages: 870-7
DOI
Peer Reviewed
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[Presentation] in vitroおよびin vivoにおける低分子化合物によるtau凝集抑制作用の検討2011
Author(s)
添田義行,吉池裕二,前田純宏,木村哲也,村山美由紀,溝呂木達也,山下俊治,柳下聡介,斎藤臣雄,長田裕之,高島明彦
Organizer
日本認知症学会
Place of Presentation
東京
Year and Date
20111111-13
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