2012 Fiscal Year Final Research Report
Clearance of neuronal exosomes in brain平成25年5月20日現在
| Project/Area Number |
23700435
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Neurochemistry/Neuropharmacology
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| Research Institution | Hokkaido University |
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Principal Investigator |
YUYAMA Kohei 北海道大学, 大学院・先端生命科学研究院, 特任助教 (80415546)
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| Project Period (FY) |
2011 – 2012
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| Keywords | エクソソーム / 中枢神経系 / アルツハイマー病 |
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| Research Abstract |
Exosome is a subtype of extracellular vesicle, released from various cells including brain neurons. A well known function of exosome is to remove obsolete or misfolded proteins from cells, however, the mechanism how exosomes are processed in extracellular space of brain remained unclear. In this study, we searched type of cells, which can uptake neuronal exosomes, and found that microglia can uptake the exosomes and degrade the exosome-associated proteins.
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