Regulation of brain functions by a protein tyrosine phosphatase SHP2

2013 Fiscal Year Final Research Report

• Project/Area Number: 23700438
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Neurochemistry/Neuropharmacology
• Research Institution: Gunma University
• Principal Investigator: SHINYA Kusakari 群馬大学, 生体調節研究所, 研究員 (10510901)
• Project Period (FY): 2011 – 2012
• Keywords: 蛋白質チロシンリン酸化 / チロシン脱リン酸化酵素 / 脳高次機能

Research Abstract

Forebrain neuron-specific KO mice of tyrosine phosphatase SHP2, a positive regulator of Ras/MAPK, show abnormal behavior including hyperactivity. In this research project, I have shown that alteration of BDNF-Ras/MAPK signal in SHP2 cKO mice is one of causes for hyperactiveity. In addition, I have found that SHP2 participates in regulation of memory and learning.

Research Products

• [Journal Article] Hypothermia-dependent and -independent effects of forced swim on the phosphorylation states of signaling molecules in mouse hippocampus (2012)
  • Author(s): Yuriko Hayashi, Shinya Kusakari, Miho Sato-Hashimoto, Eriko Urano, Masahiro Shigeno, Tsuneo Sekijima, Takenori Kotani, Yoji Murata, Hirokazu Murakami, Takashi Matozaki, Hiroshi Ohnishi
  • Journal Title: Biochemical and Biophysical Research Communications Volume: 428巻 Pages: 475-481
  • DOI: 10.1016/j.bbrc.2012.10.083
  • Peer Reviewed
• [Journal Article] Hypothermia-induced tyrosine phosphorylation of SIRPα in the brain (2012)
  • Author(s): Toshi Maruyama, Shinya Kusakari, Miho Sato-Hashimoto, Yuriko Hayashi, Takenori Kotani, Yoji Murata, Hideki Okazawa, Per-Arne Oldenborg, Shoji Kishi, Takashi Matozaki, Hiroshi Ohnishi
  • Journal Title: Journal of Neurochemistry Volume: 121巻 Pages: 891-902
  • DOI: 10.1111/j.1471-4159.2012.07748
  • Peer Reviewed
• [Journal Article] Dendritic cell-specific ablation of the protein tyrosine phosphatase Shp1 promotes Th1 cell differentiation and induces autoimmunity (2012)
  • Author(s): Tetsuya Kaneko, Yasuyuki Saito, Takenori Kotani, Hideki Okazawa, Hiroko Iwamura, Miho Sato-Hashimoto, Yoshitake Kanazawa, Satoshi Takahashi., Keiju Hiromura, Shinya Kusakari, Yoriaki Kaneko, Yoji Murata, Hiroshi Ohnishi, Yoshihisa Nojima, Keiji Takagishi, Takashi Matozaki
  • Journal Title: Journal of Immunology Volume: 188巻 Pages: 5397-5407
  • DOI: 10.4049/jimmunol.1103210
  • Peer Reviewed
• [Journal Article] Signal regulatory protein α regulates the homeostasis of T lymphocytes in the spleen (2011)
  • Author(s): Miho Sato-Hashimoto, Yasuyuki Saito, Hiroshi Ohnishi, Hiroko Iwamura, Yoshitake Kanazawa, Tetsuya Kaneko, Shinya Kusakari, Takenori Kotani, Munemasa Mori, Yoji Murata, Hideki Okazawa, Carl F. Ware, Per-Arne Oldenborg, Yoshihisa Nojima, Takashi Matozaki
  • Journal Title: Journal of Immunology Volume: 187巻 Pages: 291-297
  • DOI: 10.1111/j.1471-4159.2012.07748
  • Peer Reviewed
• [Presentation] 細胞質型チロシンホスファターゼShp2による脳機能制御 (2014)
  • Author(s): 草苅伸也、齋藤文仁、橋本美穂、柴崎貢志、吾郷由希夫、松田敏夫、Benjamin G. Neel、小谷武徳、村田陽二、的崎尚、大西浩史
  • Organizer: 第6回ホスファターゼ研究会学術集会
  • Place of Presentation: 三重大学
  • Year and Date: 20140220-21
• [Presentation] チロシンホスファターゼShp2による脳機能・行動の制御 (2014)
  • Author(s): 草苅伸也、齋藤文仁、橋本美穂、柴崎貢志、吾郷由希夫、松田敏夫、Benjamin G. Neel、小谷武徳、村田陽二、的崎尚、大西浩史
  • Organizer: 第3回群馬大学生体調節研究所内分泌・代謝学共同研究拠点シンポジウム
  • Place of Presentation: 群馬大学
  • Year and Date: 2014-01-09
• [Presentation] 細胞質型チロシンホスファターゼShp2の成熟脳における機能解析 (2013)
  • Author(s): 草苅伸也、橋本美穂、柴崎貢志、吾郷由希夫、松田敏夫、 Benjamin G. Neel、小谷武徳、村田陽二、的崎尚、大西浩史
  • Organizer: 第60回北関東医学会
  • Place of Presentation: 群馬大学
  • Year and Date: 20130926-27
• [Presentation] 成熟脳における細胞質型チロシンホスファターゼShp2の機能解析 (2013)
  • Author(s): 草苅伸也、齋藤文仁、橋本美穂、柴崎貢志、吾郷由希夫、松田敏夫、 Benjamin G. Neel、小谷武徳、村田陽二、的崎尚、大西浩史
  • Organizer: Neuro2013
  • Place of Presentation: 国立京都国際会館
  • Year and Date: 20130620-23
• [Presentation] Hypothermia-induced tyrosine phosphorylation of SIRPα in the brain (2013)
  • Author(s): Shinya Kusakari, Miho Hashimoto, Yuriko Hayashi, Eriko Urano, Yuriko Kusakari, Takenori Kotani, Yoji Murata, Hideki Okazawa, Per-Arne Oldenborg, Takashi Matozaki, Hiroshi Ohnishi
  • Organizer: 10th International Conference on Protein Phosphatases
  • Place of Presentation: がん研究振興財団国際研究交流会館
  • Year and Date: 20130207-09
• [Presentation] 細胞質型チロシンホスターゼShp2の成熟脳における機能解析 (2012)
  • Author(s): 草苅伸也、橋本美穂、柴崎貢志、吾郷由希夫、松田敏夫、 Benjamin G. Neel、小谷武徳、村田陽二、的崎尚、大西浩史
  • Organizer: 第85回日本生化学会大会
  • Place of Presentation: 福岡国際会議場
  • Year and Date: 2012-12-16
• [Presentation] Regulation of brain functions by a protein tyrosine phosphatase Shp2 (2012)
  • Author(s): Shinya Kusakari, Miho Hashimoto, Yuriko Hayashi, Yuriko Kusakari, Yukio Ago, Toshio Matsuda, Koji Shibasaki, Takenori Kotani, Yoji Murata, Benjamin G. Neel, Takashi Matozaki, Hiroshi Ohnishi
  • Organizer: 平成24年度国際シナプス研究会 International Synapse Research Workshop 2012 "Understanding of synapse pathology, from genome mutation to functional defects"
  • Place of Presentation: 岡崎コンファレンスセンター
  • Year and Date: 2012-11-07
• [Presentation] Hypothermia-induced tyrosine phosphorylation of SIRPα in the brain (2012)
  • Author(s): Shinya Kusakari, Toshi Maruyama, Miho Hashimoto-Sato, Yuriko Hayashi, Yuriko Kusakari, Takenori Kotani, Yoji Murata, Hideki Okazawa, Shoji Kishi, Takashi Matozaki, Hiroshi Ohnishi
  • Organizer: The 11th Biennial Meeting of the Asian Pacific Society for Neurochemistry, The 55th Annual Meeting of the Japanese Society for Neurochemistry
  • Place of Presentation: 神戸国際会議場
  • Year and Date: 2012-09-29
• [Presentation] 細胞質型チロシンホスターゼSh2の成熟脳における機能解析 (2012)
  • Author(s): 草苅伸也、橋本美穂、林由里子、小谷武徳、村田陽二、岡澤秀樹、吾郷由希夫、柴崎貢志、松田敏夫、 Benjamin G. Neel、的崎尚、大西浩史
  • Organizer: 第11回生体機能研究会
  • Place of Presentation: 箱根プリンスホテル
  • Year and Date: 2012-07-21
• [Presentation] 低温ストレスによる受容体型分子SIRPαのチロシンリン酸化誘導 (2012)
  • Author(s): 草苅伸也、橋本美穂、丸山登士、林由里子、草苅百合子、的崎尚、大西浩史
  • Organizer: 第30回内分泌代謝学サマーセミナー
  • Place of Presentation: 伊香保温泉福一
  • Year and Date: 2012-07-13
• [Presentation] 成熟脳におけるShp2の生理機能解析 (2012)
  • Author(s): 草苅伸也、小谷武徳、橋本美穂、村田陽二、岡澤秀樹、吾郷由希夫、松田敏夫、 Benjamin G. Neel、的崎尚、大西浩史
  • Organizer: 第5回ホスファターゼ研究会学術集会
  • Place of Presentation: 大阪大学
  • Year and Date: 2012-01-19
• [Presentation] 蛋白質チロシンホスファターゼShp2の成熟脳における機能解析 (2011)
  • Author(s): 草苅伸也、小谷武徳、橋本美穂、林由里子、草苅百合子、村田陽二、岡澤秀樹、的崎尚、大西浩史
  • Organizer: 第2回国際放射線神経生物学会大会
  • Place of Presentation: 群馬大学
  • Year and Date: 2011-12-03
• [Remarks] 研究室ホームページ
  • URL: http://biosignal.dept.med.gunma-u.ac.jp/
• [Remarks] 所属機関ホームページ
  • URL: http://www.imcr.gunma-u.ac.jp/