2013 Fiscal Year Final Research Report
Analysis of astrocyte response mechanism after brain injury
| Project/Area Number |
23700442
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Neurochemistry/Neuropharmacology
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| Research Institution | University of Yamanashi |
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Principal Investigator |
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| Project Period (FY) |
2011 – 2013
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| Keywords | アストロサイト / P2Y1受容体 / ATP / グリア瘢痕 / 神経保護 / 物理的脳損傷 |
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| Research Abstract |
Brain injury is known to activate astrocytes, however, it is unclear how they are regulated to show an oriented response to the focal brain injury. Here we demonstrate that down-regulation in astrocytic P2Y1 receptor accelerates astrocyte responses and neuroprotection after brain injury. Inhibition or knockout of P2Y1 receptor accelerated astrocyte reaction in vitro. P2Y1 receptor knockout (P2Y1KO) mouse showed accelerated astrocyte activation at early phase after brain injury and reduced a number of dead neurons which were reproduced by selective knockout of P2Y1 receptor in astrocytes. Our data highlight P2Y1 receptor-mediated-astrocyte reaction after brain injury that is essential for neuroprotective action.
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