2012 Fiscal Year Final Research Report
Intracellular transport of DISC1/Neuregulin-1 and schizophrenia
| Project/Area Number |
23700443
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Neurochemistry/Neuropharmacology
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| Research Institution | Nagoya University |
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Principal Investigator |
MORI Daisuke 名古屋大学, 医学系研究科, COE 特任講師 (00381997)
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| Project Period (FY) |
2011 – 2012
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| Keywords | 分子 / 細胞 / 神経生物学 |
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| Research Abstract |
We hypothesized that DISC1 would be involved in vesicular transport of various proteins and mRNAs which maintain neuronal function. Previously, we have identified direct interaction of DISC1 and Neuregulin-1, which is a ligand of ErbB3 and ErbB4. To understand the sense of their association, we have attempted to analyze their common interacting proteins. As a result of the comprehensive screenings, we have identified AP family proteins, which have essential roles for intracellular vesicle trafficking. Moreover, we have established a new experimental system that enables us to quantify the secretion of processed Neuregulin-1 by immunoblotting. We found that the processed Neuregulin-1 was decreased in cultured hippocampal neuron from DISC1-deficient mice. 交付決定額
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