Regulation of energy metabolism by necdin-Sirt1 complex

2012 Fiscal Year Final Research Report

• Project/Area Number: 23700445
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Neurochemistry/Neuropharmacology
• Research Institution: Osaka University
• Principal Investigator: HASEGAWA Koichi 大阪大学, たんぱく質研究所, 助教 (20546783)
• Project Period (FY): 2011 – 2012
• Keywords: エネルギー代謝 / アセチル化 / 視床下部

Research Abstract

I examined the regulation of energy metabolism-related factors by necdin-Sirt1 complex. Necdin-Sirt1 complex controlled Foxo1 acetylation and neuropeptide gene expression to modulate the hypothalamic-pituitary-thyroid axis. I also found necdin regulates the mitochondrial biogenesis and function.

Research Products

• [Journal Article] Necdin Controls Foxo1 Acetylation in Hypothalamic Arcuate Neurons to Modulate the Thyroid Axis (2012)
  • Author(s): Koichi Hasegawa, Tomohiro Kawahara, Kazushiro Fujiwara, Mayumi Shimpuku, Tsutomu Sasaki, Tadahiro Kitamura and Kazuaki Yoshikawa
  • Journal Title: The Journal of Neuroscience Volume: 32(16) Pages: 5562-5572
  • DOI: doi:10.1523/JNEUROSCI.0142-12.2012
  • Peer Reviewed
• [Journal Article] Yu-Hua Tseng and Kazuaki Yoshikawa, NecdinControls Proliferation of White Adipocyte Progenitor Cells (2012)
  • Author(s): Kazushiro Fujiwara, Koichi Hasegawa, Tsuyoshi Ohkumo, Hiroyuki Miyoshi
  • Journal Title: PLoS ONE Volume: 7(1) Pages: e30948
  • DOI: doi:10.1371/journal.pone.0030948.
  • Peer Reviewed
• [Presentation] NecdinによるPGC-1αを介したニューロン内ミトコンドリア生合成の促進 (2012)
  • Author(s): 長谷川孝一、白石千夏、藤原一志郎、吉川和明
  • Organizer: 第85回日本生化学会大会
  • Place of Presentation: 福岡
  • Year and Date: 2012-12-15
• [Presentation] 哺乳類ニューロンのDNA修復におけるNecdinの関与 (2012)
  • Author(s): 瀬戸口良、長谷川孝一、三澤昭博、吉川和明
  • Organizer: 第85回日本生化学会大会
  • Place of Presentation: 福岡
  • Year and Date: 2012-12-15
• [Presentation] In vitro SUMO化反応系によるNecdinのSUMO修飾解析 (2012)
  • Author(s): 藤原一志郎、長谷川孝一、江連徹、吉川和明
  • Organizer: 第85回日本生化学会大会
  • Place of Presentation: 福岡
  • Year and Date: 2012-12-15
• [Presentation] 視床下部Necdinによるエネルギー代謝関連因子の調節 (2012)
  • Author(s): 長谷川孝一
  • Organizer: 大阪大学蛋白質研究所セミナー「エネルギー代謝制御の分子機構」
  • Place of Presentation: 大阪
  • Year and Date: 2012-11-29
• [Presentation] Necdin suppresses preadipocyte proliferation to prevent adipocyte hyperplasia Rare Syndromic Body Fat Disorders: What Can They Teach Us? (2012)
  • Author(s): Kazushiro Fujiwara, Koichi Hasegawa, Kazuaki Yoshikaw
  • Organizer: National Institutes of Health
  • Place of Presentation: Bethesda Maryland USA
  • Year and Date: 2012-03-01
• [Presentation] Hypothalamic necdin regulates thyroid hormone-mediated energy expenditure(視床下部におけるNecdinは甲状腺ホルモンによるエネルギー消費を制御する) (2011)
  • Author(s): 白石千夏、長谷川孝一、吉川和明
  • Organizer: 第54回日本神経化学会大会
  • Place of Presentation: 石川
  • Year and Date: 2011-09-26
• [Presentation] Necdin forms multiprotein complexes with Smc5/6 components in mammalian brain(Necdinは哺乳類脳においてSmc5/6構成要素と多蛋白質複合体を形成する) (2011)
  • Author(s): 柏木裕呂樹、長谷川孝一、吉川和明
  • Organizer: 第54回日本神経化学会大会
  • Place of Presentation: 石川
  • Year and Date: 2011-09-26
• [Presentation] Necdin regulates proliferation of postnatal neural stem cells in mouse forebrain (2011)
  • Author(s): 橋長秀典、長谷川孝一、吉川和明
  • Organizer: 第84回日本生化学会大会
  • Place of Presentation: 京都
  • Year and Date: 2011-09-23
• [Presentation] Interaction between necdin and HIF-2alpha in neural stem cells (2011)
  • Author(s): 黄振宇、長谷川孝一、吉川和明
  • Organizer: 第84回日本生化学会大会
  • Place of Presentation: 京都
  • Year and Date: 2011-09-23
• [Presentation] Necdin suppresses proliferation of white adipocyte progenitor (2011)
  • Author(s): Kazushiro Fujiwara, Koichi Hasegawa, Kazuaki Yoshikawa
  • Organizer: Stem Cells in Development and Disease 2011 Max Delbruck Center
  • Place of Presentation: Berlin Germany
  • Year and Date: 2011-09-14
• [Presentation] Interplay between necdin and Bmi1 regulates proliferation of embryonic neural stem cells (2011)
  • Author(s): Ryohei Minamide, Koichi Hasegawa, Kazushiro Fujiwara, Kazuaki Yoshikawa
  • Organizer: ISN-ESN 23th Biennial Meeting
  • Place of Presentation: Athens Greece
  • Year and Date: 2011-08-30
• [Remarks] 大阪大学 蛋白質研究所 蛋白質高次機能学研究部門 神経発生制御研究室ホームページ
  • URL: http://www.protein.osaka-u.ac.jp/regulation/index_jap.html