Interaction between calcium dynamics and actin skeleton on methamphetamine-induced rewarding effects

2012 Fiscal Year Final Research Report

• Project/Area Number: 23700453
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Neurochemistry/Neuropharmacology
• Research Institution: Hoshi University
• Principal Investigator: SHIBASAKI Masahiro 星薬科大学, 薬学部, 助教 (80412162)
• Project Period (FY): 2011 – 2012
• Keywords: 覚せい剤 / 神経可塑性 / カルシウム動態 / アクチン骨格 / シナプス形成

Research Abstract

METH-conditioning significantly increased the protein levels ofADF, synaptophysin and PSD95 including the enhancement of actin turnover. In addition,increased acetylation of histone H3 was found in specific gene-promoter regions relatedto synaptic plasticity, such as synaptophysin and PSD95 showing METH-induced placepreference. These findings indicate that interaction between calcium dynamics and actinskeleton are important to the methamphetamine-induced rewarding effects.

Research Products

• [Journal Article] Involvement of the K+ -Cl- co-transporter KCC2 in the sensitization to morphine-induced hyperlocomotion under chronic treatment with zolpidem in the mesolimbic system. (2013)
  • Author(s): Shibasaki M, Masukawa D, Ishii K, Yamagishi Y, Mori T, Suzuki T.
  • Journal Title: J Neurochem Volume: (in press)
  • Peer Reviewed
• [Journal Article] Effect of chronic ethanol treatment on mu-opioid receptor function, interacting proteins and morphine-induced place preference. (2013)
  • Author(s): Shibasaki M, Watanabe K, Takeda K, ItohT, Tsuyuki T, Narita M, Mori T, Suzuki T.
  • Journal Title: Psychopharmacology (Berl) Volume: (in press)
  • Peer Reviewed
• [Journal Article] Actin dynamics in development of behavioral sensitization after withdrawal from long-term ethanol administration to mice. (2012)
  • Author(s): Shibasaki M, Kurokawa K, Mizuno K, Suzuki T, Ohkuma S.
  • Journal Title: Alcohol Clin Exp Res Volume: 36(8) Pages: 1385-1396
  • Peer Reviewed
• [Journal Article] Effect of aripiprazole on anxiety associated with ethanol physical dependence and on ethanol-induced place preference. (2012)
  • Author(s): Shibasaki M, Kurokawa K, Mizuno K, Ohkuma S
  • Journal Title: J Pharmacol Sci Volume: 118(2) Pages: 215-224
  • Peer Reviewed
• [Journal Article] Inhibitory effects of SA4503 on the rewarding effects of abused drugs. (2012)
  • Author(s): Mori T, Rahmadi M, Yoshizawa K, Itoh T, Shibasaki M, Suzuki T.
  • Journal Title: Addict Biol
  • Peer Reviewed
• [Journal Article] Effects of dronabinol on morphine-induced dopamine-related behavioral effects in animals (2012)
  • Author(s): Mori T, Shibasaki M, Abe M, Udagawa Y, Suzuki
  • Journal Title: Synapse Volume: 66(11) Pages: 931-937
  • Peer Reviewed
• [Journal Article] Olanzapine suppresses the rewarding and discriminative stimulus effects induced by morphine. (2012)
  • Author(s): Torigoe K, Mori T, Shibasaki M, Yoshizawa K, Narita M, Suzuki T
  • Journal Title: Synapse Volume: 66(2) Pages: 174-179
  • Peer Reviewed
• [Journal Article] Regulation of type 1 inositol 1,4,5-triphosphate receptor by dopamine receptors in cocaine-induced place conditioning. (2012)
  • Author(s): Kurokawa K, Mizuno K, Shibasaki M, Ohkuma S
  • Journal Title: Synapse Volume: 66(2) Pages: 180-186
  • Peer Reviewed
• [Journal Article] Up-regulation of Ca(v)1.2 subunit via facilitating trafficking induced by Vps34 on morphine-induced place preference in mice. (2011)
  • Author(s): Shibasaki M, Kurokawa K, Mizuno K, Ohkuma S
  • Journal Title: Eur J Pharmacol Volume: 651(1-3) Pages: 137-145
  • Peer Reviewed
• [Journal Article] Functional homology between alcohol dependence and mood disorder (2011)
  • Author(s): Shibasaki M, Kurokawa K, Ohkuma S.
  • Journal Title: Nihon Arukoru Yakubutsu Igakkai Zasshi Volume: 46(3) Pages: 337-346
  • Peer Reviewed
• [Journal Article] Enhancement of histoneacetylation in midbrain of mice with ethanol physical dependence and its withdrawal. (2011)
  • Author(s): Shibasaki M, Mizuno K, Kurokawa K, Ohkuma S
  • Journal Title: Synapse Volume: 65(11) Pages: 1244-1250
  • Peer Reviewed
• [Journal Article] L-type voltage-dependent calcium channels facilitate acetylation of histone H3 through PKC gamma phosphorylation in mice with methamphetamine-induced place preference. (2011)
  • Author(s): Shibasaki M, Mizuno K, Kurokawa K, Ohkuma S
  • Journal Title: J Neurochem Volume: 118(6) Pages: 1056-1066
  • Peer Reviewed
• [Journal Article] Role of actin depolymerizing factor in the development of methamphetamine-induced place preference in mice. (2011)
  • Author(s): Shibasaki M, Mizuno K, Kurokawa K, Suzuki T, Ohkuma S.
  • Journal Title: Eur J Pharmacol Volume: 671(1-3) Pages: 70-78
  • Peer Reviewed
• [Journal Article] Dopamine D1 receptor signaling system regulates ryanodine receptor expression after intermittent exposure to methamphetamine in primary cultures of midbrain and cerebral cortical neurons. (2011)
  • Author(s): Kurokawa K, Mizuno K, Kiyokage E, Shibasaki M, Toida K, Ohkuma S.
  • Journal Title: J Neurochem Volume: 118(5) Pages: 773-783
  • Peer Reviewed
• [Journal Article] Mechanism of withdrawal syndrome in alcohol dependence (2011)
  • Author(s): Shibasaki M, Mizuno K, Ohkuma S.
  • Journal Title: Nihon Arukoru Yakubutsu Igakkai Zasshi Volume: 46(5) Pages: 413-423
  • Peer Reviewed
• [Journal Article] Cocaine increases ryanodine receptors via dopamine D1 receptors. (2011)
  • Author(s): Kurokawa K, Mizuno K, Shibasaki M, Kiyokage E, Toida K, Ohkuma S.
  • Journal Title: Synapse Volume: 65(10) Pages: 1106-1112
  • Peer Reviewed
• [Journal Article] Dopamine D(1) receptors participate in cocaine-induced place preference via regulation of ryanodine receptor expression. (2011)
  • Author(s): Kurokawa K, Mizuno K, Shibasaki M, Ohkuma S.
  • Journal Title: J Pharmacol Sci Volume: 117(2) Pages: 87-97
  • Peer Reviewed
• [Journal Article] Involvement of NMDA receptors in ryanodine receptor expression in dopaminergic neurons in the ventral tegmental area of mice with intermittent methamphetamine treatment. (2011)
  • Author(s): Kurokawa K, Shibasaki M, Kiyokage E, Mizuno K, Toida K, Ohkuma S.
  • Journal Title: Synapse Volume: 65(11) Pages: 1156-1165
  • Peer Reviewed
• [Journal Article] Gabapentin blocks methamphetamine-induced sensitization and conditioned place preference via inhibition of alpha(2)/delta-1 subunits of the voltage-gated calcium channels. (2011)
  • Author(s): Kurokawa K, Shibasaki M, Mizuno K, Ohkuma S.
  • Journal Title: Neuroscience Volume: 176 Pages: 328-335
  • Peer Reviewed
• [Journal Article] beta(1)-adrenergic receptor up-regulation induced by nadolol is mediated via signal transduction pathway coupled to alpha(1)-adrenergic receptors. (2011)
  • Author(s): Mizuno K, Kurokawa K, Shibasaki M, Ohkuma S.
  • Journal Title: Brain Res Volume: 1414 Pages: 10-21
  • Peer Reviewed
• [Presentation] 薬物依存の研究( 第473 報 ) :Methamphetamine 誘発自発運動促進作用に対する lipopolysaccharides の影響 (2013)
  • Author(s): 今井敏雄, 芝崎真裕, 森友久, 鈴木勉
  • Organizer: 日本薬学会第133年会
  • Place of Presentation: 横浜
  • Year and Date: 20130327-30
• [Presentation] Zolpidemの慢性処置によるmorphine誘発報酬効果への影響 (2013)
  • Author(s): 増川太輝,芝崎真裕,森友久,石井一典,山岸ゆい,鈴木勉
  • Organizer: 第86回日本薬理学会年会
  • Place of Presentation: 福岡
  • Year and Date: 20130321-23
• [Presentation] Tsutomu Suzuki: Chronic treatment of ethanol enhanced morphine-induced (2013)
  • Author(s): Kouji Andou, Masahiro Shibasaki, Tomohisa Tsuyuki, Ami Otokozawa, Tomohisa Mori
  • Organizer: 第86回日本薬理学会年会
  • Place of Presentation: 福岡
  • Year and Date: 20130321-23
• [Presentation] アルコール依存症における脳機能変化の解析 (2013)
  • Author(s): 芝崎真裕、森友久、鈴木勉
  • Organizer: 第22回神経行動薬理若手研究者の集い
  • Place of Presentation: 福岡
  • Year and Date: 2013-03-20
• [Presentation] Effects of chronic treatment with alcohol on the morphine-induced rewarding effects.74th Annual Meeting-College on Problems of Drug Dependence (2012)
  • Author(s): Shibasaki, M., Tsuyuki, T., Takeda, K., Mori, T., Suzuki, T.
  • Organizer: 74th Annual Meeting-College on Problems of Drug Dependence
  • Place of Presentation: Califolnia
  • Year and Date: 20120609-14
• [Presentation] Effect of benzodiazepines on morphine-induced hyperlocomotion accompanied by the changes of KCC2 in the nucleus accumbens (2012)
  • Author(s): Masukawa, D., Shibasaki, M., Mori, T., Ishii, K., Saitoh, Y., Yamagishi, Y., Suzuki, T
  • Organizer: 74th Annual Meeting-College on Problems of Drug Dependence
  • Place of Presentation: Califolnia
  • Year and Date: 20120609-14
• [Presentation] アルコール慢性処置に対するモルヒネの報酬効果と鎮痛効果の影響 (2012)
  • Author(s): 露木智久,芝崎真裕,武田弘太郎,森友久,
  • Organizer: 第85回日本薬理学会年会
  • Place of Presentation: 京都
  • Year and Date: 20120314-16
• [Presentation] アルコール慢性処置のモルヒネ誘発報酬効果におけるGSK3 ss signalcascadeの影響 (2012)
  • Author(s): 露木智久,芝崎真裕,安藤光史,男澤杏美,森友久,鈴木勉
  • Organizer: 第127回日本薬理学会関東部会
  • Place of Presentation: 東京
  • Year and Date: 2012-10-20
• [Presentation] Influence Of Chronic Treatment Of Zolpidem On Activation Of Dopaminergic System In Nuculeus Accumbence (2012)
  • Author(s): Masukawa, D., Shibasaki, M., Mori, T., Ishii, K., Yamagishi, Y., Suzuki, T.
  • Organizer: 16th Congress of International Society for Biomedical research on Alcoholism
  • Place of Presentation: 札幌
  • Year and Date: 2012-09-12
• [Presentation] Chronic Ethanol Treatment Alters Morphine-Induced Rewarding Effect Through Mor Receptor-Mediated Functional Changes (2012)
  • Author(s): Tsuyuki, T., Shibasaki, M., Takeda, K., Mori, T., Suzuki, T.
  • Organizer: 16th Congress of International Society for Biomedical research on Alcoholism
  • Place of Presentation: 札幌
  • Year and Date: 2012-09-12
• [Presentation] Lipopolysaccharides (LPS)によるミクログリアの活性化がmethamphetamine誘発報酬効果に及ぼす影響 (2012)
  • Author(s): 増川太輝,芝崎真裕,秋田由花子,三竹真里子,森友久,鈴木勉
  • Organizer: 第21回神経行動薬理若手研究者の集
  • Place of Presentation: 京都
  • Year and Date: 2012-03-13
• [Presentation] Benzodiazepine系薬物の中脳辺縁系に及ぼす影響 (2011)
  • Author(s): 増川太輝,芝崎真裕,森友久,石井一典,斉藤祐輔,山岸ゆい,鈴木勉
  • Organizer: 第21回日本臨床精神神経薬理学会
  • Place of Presentation: 東京
  • Year and Date: 20111027-29
• [Presentation] Methamphetamine誘発報酬効果に対するlipopolysaccharides(LPS)の影響と脳内mRNA発現変動の解析 (2011)
  • Author(s): 秋田由花子,芝崎真裕,増川太輝,森友久,鈴木勉
  • Organizer: 第21回日本臨床精神神経薬理学会・第41回日本神経精神薬理学会年会
  • Place of Presentation: 東京
  • Year and Date: 20111027-29
• [Presentation] アルコール慢性処置によるモルヒネ誘発報酬効果の変化 (2011)
  • Author(s): 武田弘太郎,芝崎真裕,露木智久,森友久,鈴木勉
  • Organizer: アルコール精神依存関連学会合同学術総会
  • Place of Presentation: 名古屋
  • Year and Date: 20111013-15
• [Presentation] Morphine 誘発報酬効果に対する cannabinoid 1 受容体作動薬の影響 (2011)
  • Author(s): 阿部美奈子,芝崎真裕,森友久,鈴木勉
  • Organizer: 第21回日本臨床精神神経薬理学会・第41回日本神経精神薬理学会年会
  • Place of Presentation: 東京
  • Year and Date: 2011-10-27
• [Remarks]
  • URL: http://polaris.hoshi.ac.jp/kyoshitsu/dokusei/home/Top.html