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2012 Fiscal Year Final Research Report

Interaction between calcium dynamics and actin skeleton on methamphetamine-induced rewarding effects

Research Project

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Project/Area Number 23700453
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Neurochemistry/Neuropharmacology
Research InstitutionHoshi University

Principal Investigator

SHIBASAKI Masahiro  星薬科大学, 薬学部, 助教 (80412162)

Project Period (FY) 2011 – 2012
Keywords覚せい剤 / 神経可塑性 / カルシウム動態 / アクチン骨格 / シナプス形成
Research Abstract

METH-conditioning significantly increased the protein levels ofADF, synaptophysin and PSD95 including the enhancement of actin turnover. In addition,increased acetylation of histone H3 was found in specific gene-promoter regions relatedto synaptic plasticity, such as synaptophysin and PSD95 showing METH-induced placepreference. These findings indicate that interaction between calcium dynamics and actinskeleton are important to the methamphetamine-induced rewarding effects.

  • Research Products

    (36 results)

All 2013 2012 2011 Other

All Journal Article (20 results) (of which Peer Reviewed: 20 results) Presentation (15 results) Remarks (1 results)

  • [Journal Article] Involvement of the K+ -Cl- co-transporter KCC2 in the sensitization to morphine-induced hyperlocomotion under chronic treatment with zolpidem in the mesolimbic system.2013

    • Author(s)
      Shibasaki M, Masukawa D, Ishii K, Yamagishi Y, Mori T, Suzuki T.
    • Journal Title

      J Neurochem

      Volume: (in press)

    • Peer Reviewed
  • [Journal Article] Effect of chronic ethanol treatment on mu-opioid receptor function, interacting proteins and morphine-induced place preference.2013

    • Author(s)
      Shibasaki M, Watanabe K, Takeda K, ItohT, Tsuyuki T, Narita M, Mori T, Suzuki T.
    • Journal Title

      Psychopharmacology (Berl)

      Volume: (in press)

    • Peer Reviewed
  • [Journal Article] Actin dynamics in development of behavioral sensitization after withdrawal from long-term ethanol administration to mice.2012

    • Author(s)
      Shibasaki M, Kurokawa K, Mizuno K, Suzuki T, Ohkuma S.
    • Journal Title

      Alcohol Clin Exp Res

      Volume: 36(8) Pages: 1385-1396

    • Peer Reviewed
  • [Journal Article] Effect of aripiprazole on anxiety associated with ethanol physical dependence and on ethanol-induced place preference.2012

    • Author(s)
      Shibasaki M, Kurokawa K, Mizuno K, Ohkuma S
    • Journal Title

      J Pharmacol Sci

      Volume: 118(2) Pages: 215-224

    • Peer Reviewed
  • [Journal Article] Inhibitory effects of SA4503 on the rewarding effects of abused drugs.2012

    • Author(s)
      Mori T, Rahmadi M, Yoshizawa K, Itoh T, Shibasaki M, Suzuki T.
    • Journal Title

      Addict Biol

    • Peer Reviewed
  • [Journal Article] Effects of dronabinol on morphine-induced dopamine-related behavioral effects in animals2012

    • Author(s)
      Mori T, Shibasaki M, Abe M, Udagawa Y, Suzuki
    • Journal Title

      Synapse

      Volume: 66(11) Pages: 931-937

    • Peer Reviewed
  • [Journal Article] Olanzapine suppresses the rewarding and discriminative stimulus effects induced by morphine.2012

    • Author(s)
      Torigoe K, Mori T, Shibasaki M, Yoshizawa K, Narita M, Suzuki T
    • Journal Title

      Synapse

      Volume: 66(2) Pages: 174-179

    • Peer Reviewed
  • [Journal Article] Regulation of type 1 inositol 1,4,5-triphosphate receptor by dopamine receptors in cocaine-induced place conditioning.2012

    • Author(s)
      Kurokawa K, Mizuno K, Shibasaki M, Ohkuma S
    • Journal Title

      Synapse

      Volume: 66(2) Pages: 180-186

    • Peer Reviewed
  • [Journal Article] Up-regulation of Ca(v)1.2 subunit via facilitating trafficking induced by Vps34 on morphine-induced place preference in mice.2011

    • Author(s)
      Shibasaki M, Kurokawa K, Mizuno K, Ohkuma S
    • Journal Title

      Eur J Pharmacol

      Volume: 651(1-3) Pages: 137-145

    • Peer Reviewed
  • [Journal Article] Functional homology between alcohol dependence and mood disorder2011

    • Author(s)
      Shibasaki M, Kurokawa K, Ohkuma S.
    • Journal Title

      Nihon Arukoru Yakubutsu Igakkai Zasshi

      Volume: 46(3) Pages: 337-346

    • Peer Reviewed
  • [Journal Article] Enhancement of histoneacetylation in midbrain of mice with ethanol physical dependence and its withdrawal.2011

    • Author(s)
      Shibasaki M, Mizuno K, Kurokawa K, Ohkuma S
    • Journal Title

      Synapse

      Volume: 65(11) Pages: 1244-1250

    • Peer Reviewed
  • [Journal Article] L-type voltage-dependent calcium channels facilitate acetylation of histone H3 through PKC gamma phosphorylation in mice with methamphetamine-induced place preference.2011

    • Author(s)
      Shibasaki M, Mizuno K, Kurokawa K, Ohkuma S
    • Journal Title

      J Neurochem

      Volume: 118(6) Pages: 1056-1066

    • Peer Reviewed
  • [Journal Article] Role of actin depolymerizing factor in the development of methamphetamine-induced place preference in mice.2011

    • Author(s)
      Shibasaki M, Mizuno K, Kurokawa K, Suzuki T, Ohkuma S.
    • Journal Title

      Eur J Pharmacol

      Volume: 671(1-3) Pages: 70-78

    • Peer Reviewed
  • [Journal Article] Dopamine D1 receptor signaling system regulates ryanodine receptor expression after intermittent exposure to methamphetamine in primary cultures of midbrain and cerebral cortical neurons.2011

    • Author(s)
      Kurokawa K, Mizuno K, Kiyokage E, Shibasaki M, Toida K, Ohkuma S.
    • Journal Title

      J Neurochem

      Volume: 118(5) Pages: 773-783

    • Peer Reviewed
  • [Journal Article] Mechanism of withdrawal syndrome in alcohol dependence2011

    • Author(s)
      Shibasaki M, Mizuno K, Ohkuma S.
    • Journal Title

      Nihon Arukoru Yakubutsu Igakkai Zasshi

      Volume: 46(5) Pages: 413-423

    • Peer Reviewed
  • [Journal Article] Cocaine increases ryanodine receptors via dopamine D1 receptors.2011

    • Author(s)
      Kurokawa K, Mizuno K, Shibasaki M, Kiyokage E, Toida K, Ohkuma S.
    • Journal Title

      Synapse

      Volume: 65(10) Pages: 1106-1112

    • Peer Reviewed
  • [Journal Article] Dopamine D(1) receptors participate in cocaine-induced place preference via regulation of ryanodine receptor expression.2011

    • Author(s)
      Kurokawa K, Mizuno K, Shibasaki M, Ohkuma S.
    • Journal Title

      J Pharmacol Sci

      Volume: 117(2) Pages: 87-97

    • Peer Reviewed
  • [Journal Article] Involvement of NMDA receptors in ryanodine receptor expression in dopaminergic neurons in the ventral tegmental area of mice with intermittent methamphetamine treatment.2011

    • Author(s)
      Kurokawa K, Shibasaki M, Kiyokage E, Mizuno K, Toida K, Ohkuma S.
    • Journal Title

      Synapse

      Volume: 65(11) Pages: 1156-1165

    • Peer Reviewed
  • [Journal Article] Gabapentin blocks methamphetamine-induced sensitization and conditioned place preference via inhibition of alpha(2)/delta-1 subunits of the voltage-gated calcium channels.2011

    • Author(s)
      Kurokawa K, Shibasaki M, Mizuno K, Ohkuma S.
    • Journal Title

      Neuroscience

      Volume: 176 Pages: 328-335

    • Peer Reviewed
  • [Journal Article] beta(1)-adrenergic receptor up-regulation induced by nadolol is mediated via signal transduction pathway coupled to alpha(1)-adrenergic receptors.2011

    • Author(s)
      Mizuno K, Kurokawa K, Shibasaki M, Ohkuma S.
    • Journal Title

      Brain Res

      Volume: 1414 Pages: 10-21

    • Peer Reviewed
  • [Presentation] 薬物依存の研究( 第473 報 ) :Methamphetamine 誘発自発運動促進作用に対する lipopolysaccharides の影響2013

    • Author(s)
      今井敏雄, 芝崎真裕, 森友久, 鈴木勉
    • Organizer
      日本薬学会第133年会
    • Place of Presentation
      横浜
    • Year and Date
      20130327-30
  • [Presentation] Zolpidemの慢性処置によるmorphine誘発報酬効果への影響2013

    • Author(s)
      増川太輝,芝崎真裕,森友久,石井一典,山岸ゆい,鈴木勉
    • Organizer
      第86回日本薬理学会年会
    • Place of Presentation
      福岡
    • Year and Date
      20130321-23
  • [Presentation] Tsutomu Suzuki: Chronic treatment of ethanol enhanced morphine-induced2013

    • Author(s)
      Kouji Andou, Masahiro Shibasaki, Tomohisa Tsuyuki, Ami Otokozawa, Tomohisa Mori
    • Organizer
      第86回日本薬理学会年会
    • Place of Presentation
      福岡
    • Year and Date
      20130321-23
  • [Presentation] アルコール依存症における脳機能変化の解析2013

    • Author(s)
      芝崎真裕、森友久、鈴木勉
    • Organizer
      第22回神経行動薬理若手研究者の集い
    • Place of Presentation
      福岡
    • Year and Date
      2013-03-20
  • [Presentation] Effects of chronic treatment with alcohol on the morphine-induced rewarding effects.74th Annual Meeting-College on Problems of Drug Dependence2012

    • Author(s)
      Shibasaki, M., Tsuyuki, T., Takeda, K., Mori, T., Suzuki, T.
    • Organizer
      74th Annual Meeting-College on Problems of Drug Dependence
    • Place of Presentation
      Califolnia
    • Year and Date
      20120609-14
  • [Presentation] Effect of benzodiazepines on morphine-induced hyperlocomotion accompanied by the changes of KCC2 in the nucleus accumbens2012

    • Author(s)
      Masukawa, D., Shibasaki, M., Mori, T., Ishii, K., Saitoh, Y., Yamagishi, Y., Suzuki, T
    • Organizer
      74th Annual Meeting-College on Problems of Drug Dependence
    • Place of Presentation
      Califolnia
    • Year and Date
      20120609-14
  • [Presentation] アルコール慢性処置に対するモルヒネの報酬効果と鎮痛効果の影響2012

    • Author(s)
      露木智久,芝崎真裕,武田弘太郎,森友久,
    • Organizer
      第85回日本薬理学会年会
    • Place of Presentation
      京都
    • Year and Date
      20120314-16
  • [Presentation] アルコール慢性処置のモルヒネ誘発報酬効果におけるGSK3 ss signalcascadeの影響2012

    • Author(s)
      露木智久,芝崎真裕,安藤光史,男澤杏美,森友久,鈴木勉
    • Organizer
      第127回日本薬理学会関東部会
    • Place of Presentation
      東京
    • Year and Date
      2012-10-20
  • [Presentation] Influence Of Chronic Treatment Of Zolpidem On Activation Of Dopaminergic System In Nuculeus Accumbence2012

    • Author(s)
      Masukawa, D., Shibasaki, M., Mori, T., Ishii, K., Yamagishi, Y., Suzuki, T.
    • Organizer
      16th Congress of International Society for Biomedical research on Alcoholism
    • Place of Presentation
      札幌
    • Year and Date
      2012-09-12
  • [Presentation] Chronic Ethanol Treatment Alters Morphine-Induced Rewarding Effect Through Mor Receptor-Mediated Functional Changes2012

    • Author(s)
      Tsuyuki, T., Shibasaki, M., Takeda, K., Mori, T., Suzuki, T.
    • Organizer
      16th Congress of International Society for Biomedical research on Alcoholism
    • Place of Presentation
      札幌
    • Year and Date
      2012-09-12
  • [Presentation] Lipopolysaccharides (LPS)によるミクログリアの活性化がmethamphetamine誘発報酬効果に及ぼす影響2012

    • Author(s)
      増川太輝,芝崎真裕,秋田由花子,三竹真里子,森友久,鈴木勉
    • Organizer
      第21回神経行動薬理若手研究者の集
    • Place of Presentation
      京都
    • Year and Date
      2012-03-13
  • [Presentation] Benzodiazepine系薬物の中脳辺縁系に及ぼす影響2011

    • Author(s)
      増川太輝,芝崎真裕,森友久,石井一典,斉藤祐輔,山岸ゆい,鈴木勉
    • Organizer
      第21回日本臨床精神神経薬理学会
    • Place of Presentation
      東京
    • Year and Date
      20111027-29
  • [Presentation] Methamphetamine誘発報酬効果に対するlipopolysaccharides(LPS)の影響と脳内mRNA発現変動の解析2011

    • Author(s)
      秋田由花子,芝崎真裕,増川太輝,森友久,鈴木勉
    • Organizer
      第21回日本臨床精神神経薬理学会・第41回日本神経精神薬理学会年会
    • Place of Presentation
      東京
    • Year and Date
      20111027-29
  • [Presentation] アルコール慢性処置によるモルヒネ誘発報酬効果の変化2011

    • Author(s)
      武田弘太郎,芝崎真裕,露木智久,森友久,鈴木勉
    • Organizer
      アルコール精神依存関連学会合同学術総会
    • Place of Presentation
      名古屋
    • Year and Date
      20111013-15
  • [Presentation] Morphine 誘発報酬効果に対する cannabinoid 1 受容体作動薬の影響2011

    • Author(s)
      阿部美奈子,芝崎真裕,森友久,鈴木勉
    • Organizer
      第21回日本臨床精神神経薬理学会・第41回日本神経精神薬理学会年会
    • Place of Presentation
      東京
    • Year and Date
      2011-10-27
  • [Remarks]

    • URL

      http://polaris.hoshi.ac.jp/kyoshitsu/dokusei/home/Top.html

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Published: 2014-09-25  

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