2013 Fiscal Year Final Research Report
Functional significance of microtubuledynamics controlled counteractively by cAMP and cGMP
| Project/Area Number |
23700456
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Neurochemistry/Neuropharmacology
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| Research Institution | The Institute of Physical and Chemical Research |
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Principal Investigator |
AKIYAMA Hiroki 独立行政法人理化学研究所, 脳科学総合研究センター, 基礎科学特別研究員 (40568854)
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| Project Period (FY) |
2011 – 2013
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| Keywords | 軸索ガイダンス / 成長円錐 / cAMP / cGMP / 微小管 |
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| Research Abstract |
During development, neurons extend axons to make connections with the targets. The growth cone at the tip of the elongating axon senses guidance cues in the extracellular environment and thus plays a central role in establishing the proper connections. Elucidating intracellular events mediating growth cone steering is essential for understanding the basis of neuronal circuit assembly. In this project, I showed that cyclic nucleotides mediate axon guidance by regulating microtubule-dependent vesicle transport in the growth cones.
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