2013 Fiscal Year Final Research Report
Metabotropic glutamate receptor regulates Schwann cell differentiation and proliferation
| Project/Area Number |
23700462
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Neurochemistry/Neuropharmacology
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| Research Institution | Tokyo Women's Medical University (2012)
National Center of Neurology and Psychiatry (2011) |
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Principal Investigator |
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| Project Period (FY) |
2011 – 2013
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| Keywords | シュワン細胞 / 代謝型グルタミン酸受容体 |
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| Research Abstract |
Glutamate promotes Schwann cells proliferation and inhibits Schwann cell myelination, but its precise mechanism has remained unclear. We found that glutamate activates Erk signaling, which is important for Schwann cell de-differentiation and proliferation. This glutamate mediated Erk activation was blocked by mGluR2/3 antagonist. Furthermore, blockade of mGluR2 signaling promotes differentiation. These results indicate that the glutamate-mGluR2 signaling may play an important role in regulating Schwann cell differentiation and proliferation.
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