2013 Fiscal Year Final Research Report
The Role of Sleep in the Reorganization of the Cerebral Cortex
| Project/Area Number |
23700464
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Neurophysiology and muscle physiology
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| Research Institution | Tohoku University |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
NAKAO Mitsuyuki 東北大学, 大学院情報科学研究科, 教授 (20172265)
KATAYAMA Norihiro 東北大学, 大学院情報科学研究科, 准教授 (20282030)
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| Project Period (FY) |
2011 – 2013
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| Keywords | 睡眠 / ノンレム睡眠 / 大脳皮質 / シナプス可塑性 / AMPA受容体 / 神経回路 |
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| Research Abstract |
Recently, the relationship between sleep-wake rhythm and synaptic plasticity is investigated by many sleep researchers. They suggest that the synaptic connection became stronger during wakefulness and became weaker during sleep. In order to confirm this suggestion, we performed whole-cell patch-clamp recordings from layer II/III pyramidal neurons of somatosensory cortex in acute slices of the rats that had been awake or asleep. We found that i) current-voltage relationship of EPSCs showed inward rectification, and ii) eEPSCs were depressed by Philanthotoxin 74, which is antagonist of Ca2+-permeable AMPA receptors, in slices of spontaneously waking and sleep-deprived animals. Both results show that amount of Ca2+permeable AMPA receptors, which plays crucial role in synaptic plasticity, are high during wakefulness. These strongly suggest that synapses become widely potentiated during wakefulness and were downscaled during sleep.
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