2013 Fiscal Year Final Research Report
Neural control of saccades by the fastigial nucleus
| Project/Area Number |
23700466
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Neurophysiology and muscle physiology
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| Research Institution | Tokyo Medical and Dental University |
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Principal Investigator |
TAKAHASHI Mayu 東京医科歯科大学, 医歯(薬)学総合研究科, 助教 (50581344)
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| Project Period (FY) |
2011 – 2013
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| Keywords | 姿勢・運動制御 / 眼球運動 |
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| Research Abstract |
To understand the functional role of the oculomotor fastigial nucleus (oFN) for control of saccades, we analyzed the inputs to and the output from the oFN using electrophysiological and anatomical methods. The projection from the oFN terminated densely in the area caudal to the abducens nucleus, but scarcely in the area rostral to it. Neurons in the NRG received strong excitation from the oFN, whereas neurons in the NRPc received almost no excitation. These data suggested that neurons in the NRG that project to the cervical MN are related to motor control of gaze (eye and head). In fact, NRG neurons received strong monosynaptic excitation from the contralateral superior colliculus and disynaptic excitation from the ipsilateral one.
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