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2012 Fiscal Year Final Research Report

Long-term reward value coding by midbrain dopamine neurons

Research Project

  • PDF
Project/Area Number 23700503
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Fusional social brain science
Research InstitutionTamagawa University

Principal Investigator

ENOMOTO Kazuki  玉川大学, 脳科学研究所, 嘱託研究員 (10585904)

Project Period (FY) 2011 – 2012
Keywordsドーパミン / 霊長類 / 報酬価値 / 予測誤差 / 意思決定 / 強化学習 / 大脳基底核
Research Abstract

We showed that midbrain dopamine neurons encode long-term value and its expectation errors of future rewards. By using electrophysiological methods and computational simulations based on reinforcement learning theories, we recorded and analyzed dopamine neuron responses in monkeys performing a behavioral task in which they obtained multiple rewards by multi-step actions. We also confirmed that dopamine neurons evolved these activities by learning the task. These functions play an important role in decision-making and action selection to achieve a distant goal.

  • Research Products

    (9 results)

All 2013 2012 2011 Other

All Journal Article (2 results) (of which Peer Reviewed: 2 results) Presentation (4 results) Book (1 results) Remarks (2 results)

  • [Journal Article] Coding of the long-term value of multiple future rewards in the primate striatum2013

    • Author(s)
      Yamada H, Inokawa H, Matsumoto N, Ueda Y, Enomoto K, Kimura M.
    • Journal Title

      J Neurophysiol

      Volume: 109(4) Pages: 1140-1151

    • DOI

      DOI:10.1152/jn.00289.2012

    • Peer Reviewed
  • [Journal Article] Dopamine neurons learn to encode the long-term value of multiple future rewards2011

    • Author(s)
      Enomoto K, Matsumoto N, Nakai S, Satoh T, Sato TK, Ueda Y, Inokawa H, Haruno M, Kimura M
    • Journal Title

      Proceedings of the National Academy of Sciences

      Volume: 108(37) Pages: 15462-15467

    • DOI

      DOI:10.1073/pnas.1014457108

    • Peer Reviewed
  • [Presentation] Location-specific roles of dopamine neurons in the midbrain in learning and decision-making2012

    • Author(s)
      Enomoto K, Matsumoto N, Kimura M
    • Organizer
      Neuroscience 2012 (SfN's 42nd annual meeting)
    • Place of Presentation
      Ernest N. Morial Convention Center, New Orleans, USA
    • Year and Date
      2012-10-13
  • [Presentation] ドーパミン神経系による予測と意思決定の制御機構(霊長類における研究を中心に)2012

    • Author(s)
      榎本一紀
    • Organizer
      第34回日本生物学的精神医学会
    • Place of Presentation
      神戸国際会議場, 兵庫県
    • Year and Date
      2012-09-28
  • [Presentation] 学習と意思決定課題におけるサルの中脳部位特異的なドーパミン細胞の活動 Heterogeneous signals of midbrain dopamine neurons during learning and decision-making2012

    • Author(s)
      榎本一紀, 松本直幸, 木村實
    • Organizer
      第35回日本神経科学大会
    • Place of Presentation
      名古屋国際会議場, 愛知県
    • Year and Date
      2012-09-18
  • [Presentation] 中脳ドーパミン細胞による、異なった時間スケールでの報酬価値とその誤差の表現 Midbrain dopamine neurons encode reward value and its error on heterogeneous time scale2012

    • Author(s)
      榎本一紀, 松本直幸, 木村實
    • Organizer
      第34回日本神経科学大会
    • Place of Presentation
      パシフィコ横浜, 神奈川県
    • Year and Date
      2012-09-16
  • [Book] 実験医学増刊2012

    • Author(s)
      榎本一紀, 木村實
    • Total Pages
      257
    • Publisher
      羊土社
  • [Remarks]

    • URL

      http://physiology.jp/exec/page/stopics76

  • [Remarks]

    • URL

      http://brainprogram.mext.go.jp/media/press/110905tamagawa_kimura_press2.pdf

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Published: 2014-09-25  

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