2012 Fiscal Year Final Research Report
The roles of PRR and cytokines in the development of intestinal microbiota-dependent inflammatory bowel diseases
Project/Area Number |
23700508
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Multi-year Fund |
Research Field |
Laboratory animal science
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Research Institution | Tokyo University of Science (2012) The University of Tokyo (2011) |
Principal Investigator |
TANG Ce 東京理科大学, 生命医科学研究所, 助教 (00572166)
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Project Period (FY) |
2010 – 2012
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Keywords | C型レクチン / 腸内細菌叢 / サイトカイン / 炎症性腸疾患 / 遺伝子欠損マウス |
Research Abstract |
The intestinal immune system has to take dual tasks; the system should fight against invading pathogens and, at the same time, the system should be tolerant toward commensal microbiota or food components. Dectin-1 is the receptor for beta-glucans expressed in fungal cell walls and activates the immune system toprevent infection. Because beta-glucans are contained in wide variety of foods and commensal microbiota, we investigated the effects of Dectin-1 signaling on the intestinal immunity. We found that Dectin-1-deficient mice were refractory to dextran sodium sulfate-induced colitis, a model for inflammatory bowel diseases, due to expansion of one genus of Gram-positive commensal bacteria in the colon associated with remodification of T cell subpopulations. Furthermore, oral administration of a seaweed-derived Dectin-1 antagonist, inhibited the proinflammatory cytokine production in colonic lamina propria cells and suppressed the development of colitis. These observations suggest that inhibition of Dectin-1 signaling in the colon regulates the balance of intestinal microbiota and cellular immunity, and further suppresses the development of inflammatory bowel diseases.
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Research Products
(5 results)
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[Journal Article] The Antimicrobial Protein REG3A Regulates Keratinocyte Proliferation and Differentiation after Skin Injury2012
Author(s)
Yuping Lai, Dongqing Li, Changwei Li, Beda Muehleisen, Katherine A. Radek, Hyun Jeong Park, Ziwei Jiang, Zhiheng Li, Hu Lei, Yanchun Quan, Tian Zhang, Yelin Wu, Paul Kotol, Shin Morizane, Tissa R. Hata, Keiji Iwatsuki, Ce Tang, and Richard L. Gallo
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Journal Title
Immunity.
Volume: 37(1)
Pages: 74-84.
Peer Reviewed
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