2012 Fiscal Year Final Research Report
Establishment of HIV-1-infected mouse model using HLA-expressedhumanized mice, and the analysis of immune response in the mice.
| Project/Area Number |
23700513
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Laboratory animal science
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| Research Institution | Kumamoto University |
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Principal Investigator |
SATO Yoshinori 熊本大学, エイズ学研究センター, COE リサーチ・アソシエイト (90455402)
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| Research Collaborator |
NAGATA Sayaka 熊本大学, エイズ学研究センター, 技術補佐員
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| Project Period (FY) |
2011 – 2012
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| Keywords | ヒト化マウス / HIV -1 感染症 / ヒト T 細胞 |
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| Research Abstract |
A small animal model for the analysis of HIV -1 infection has notbeen established yet. T o establish the animal model, we generated new humanized miceand investigated the responses of human T cells against HIV -1 in the mice. HIV -1 wasdetected in plasma of the mice after HIV -1 infection and the number of CD4 T cells in themice decreased. Also, effector CD8 T cells which are important for the elimination ofHIV -1-infected cells were induced in the mice after HIV -1 infection. These results indicatethat a humanized mouse model will be available for the analysis of HIV -1 infection
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