2012 Fiscal Year Final Research Report
Analysis of reverse transmigration of monocytes across endothelium as the anti-atherogenic system.
| Project/Area Number |
23700546
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Biomedical engineering/Biological material science
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| Research Institution | Kawasaki Medical School |
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Principal Investigator |
HASHIMOTO Ken 川崎医科大学, 医学部, 講師 (80341080)
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| Project Period (FY) |
2011 – 2012
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| Keywords | 動脈硬化 / 血管内皮細胞 / 単球 / 逆浸潤 / TRPV2 |
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| Research Abstract |
Pathophysiological significance of momocyte reverse transmigration from subendothelium back into the blood stream during atherogenesis is unclear. We established the quantitative evaluation system of reverse transmigration, and revealed that high dose of IL-1β selectively impaired the process. This suggests that in strong inflammatory conditions like atherosclerosis, the clearance activity of pathogenic substances in subendothelium is impaired due to suppressed reverse transmigration. Meanwhile, mechanical stimulations like membrane stretch are generated at the border of migrating monocytes and endothelial cells. We evaluated the role of TRPV2, previously reported mechano-sensitive cation channels, and demonstrated its necessity for cells to move.
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[Journal Article] Increased Passive Stiffness of Cardiomyocytes in the Transverse Direction and Residual Actin and Myosin Cross-Bridge Formation in Hypertrophied Rat Hearts Induced by Chronic β -Adrenergic Stimulation.2013
Author(s)
Sumita Yoshikawa W, Nakamura K, Miura D, Shimizu J, Hashimoto K, Kataoka N, Toyota H, Okuyama H, Miyoshi T, Morita H, Fukushima Kusano K, Matsuo T, Takaki M, Kajiya F, Yagi N, Ohe T, Ito H.
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Journal Title
Circ J
Volume: 77(3)
Pages: 741-8
Peer Reviewed
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[Journal Article] Monocyte trans-endothelial migration augments subsequent transmigratory activity with increased PECAM-1 and decreased VE-cadherin at endothelial junctions.2010
Author(s)
Hashimoto K, Kataoka N, Nakamura E, Hagihara K, Hatano M, Okamoto T, Kanouchi H, Minatogawa Y, Mohri S, Tsujioka K, Kajiya F.
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Journal Title
Int J Cardiol
Volume: 149(2)
Pages: 232-9
Peer Reviewed
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