2012 Fiscal Year Final Research Report
System Analysis of Sympathetic Regulation of Heart Failure and Exploration of New Bionic Autonomic Neuromodulation Therapy
| Project/Area Number |
23700550
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Biomedical engineering/Biological material science
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| Research Institution | National Cardiovascular Center Research Institute |
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Principal Investigator |
SATA Yusuke 独立行政法人国立循環器病研究センター, 研究所, 流動研究員 (70570258)
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| Research Collaborator |
SUGIMACHI Masaru 独立行政法人国立循環器病研究センター, 研究所, 部長
KAWADA Toru 独立行政法人国立循環器病研究センター, 研究所, 室長
SHIMIZU Shuji 独立行政法人国立循環器病研究センター, 研究所, 特認研究員
KAMIYA Atsunori 独立行政法人国立循環器病研究センター, 研究所, 研究員
AKIYAMA Tsuyoshi 独立行政法人国立循環器病研究センター, 研究所, 室長
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| Project Period (FY) |
2011 – 2012
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| Keywords | 生体制御 / システム生理 / 心不全 / 高血圧 / 自律神経 |
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| Research Abstract |
To elucidate the mechanisms of sympathetic regulation in heart failure, we examined sympathetic nervous activity and blood pressure in response to change in isolated carotid sinus pressure in spontaneously hypertensive rats (SHR), as hypertension is considered the major cause of heart failure. The neural arc, the sympathetic nerve activity in response to carotid sinus pressure, shifted towards a higher set point whereas the peripheral arc, the pressor response to sympathetic nerve activity, did not change when compared with normotensive Wistar Kyoto Rats (WKY). Renal sympathetic nerve denervation in SHR reduced blood pressure not only through baroreflex regulation, but also baroreflex-independently by shifting the neural arc towards a lower set point. The antihypertensive effects of renal denervation did not completely normalize either blood pressure or sympathetic nervous activity to the levels seen in WKY. As a conclusion, the neuromodulation therapy, renal denervation, reduced sympathetic nervous activity, and, through the baroreflex regulation of sympathetic nervous activity, decreased blood pressure in renal denervated SHR compared to SHR.
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