2012 Fiscal Year Final Research Report
Fabrication of Complex Hydrogel Materials with Microscale Patterns for Cell Organization
| Project/Area Number |
23700554
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Biomedical engineering/Biological material science
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| Research Institution | Chiba University |
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Principal Investigator |
YAMADA Masumi 千葉大学, 大学院・工学研究科, 准教授 (30546784)
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| Project Period (FY) |
2011 – 2012
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| Keywords | バイオマテリアル / マイクロ流路 / ハイドロゲル |
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| Research Abstract |
We developed microfluidic systems for preparing complex hydrogel materials embedding micrometer-patterns with different physicochemical properties. Complex hydrogel fibers, stripe-patterned sheets, cell-sized ECM particles, and planar patterns were fabricated. These materials were applied to, for example, the coculture of primary hepatocytes and non-parenchymal cells, the formation of heterogeneous spheroids incorporating ECM particles, and the preparation of relatively large tissues by combining these unit materials. In addition, strategies for preparing vascular tissue models have been proposed using microfluidic devices made of hydrogel.
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