2012 Fiscal Year Final Research Report
Non-invasive tumor therapy byusing ultrasound NO generation
| Project/Area Number |
23700581
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
|
| Allocation Type | Multi-year Fund |
|---|
| Research Field |
Medical systems
|
|---|
| Research Institution | Jikei University School of Medicine |
|---|
Principal Investigator |
ENDOH Reiko 東京慈恵会医科大学, 医学部, 助教 (40433982)
|
|---|
| Project Period (FY) |
2011 – 2012
|
| Keywords | 低侵襲治療システム / 超音波NO産生 |
|---|
| Research Abstract |
Our goal is non-invasive tumor therapy by using ultrasound Nitric Oxide (NO) generation. In this study, we established a measurement model of NO generation with a normal tissue. The ultrasound NO generation with a normal tissue was lower compared with a tumor. Tumor-bearing rats were prepared, and the influence on tumor vessels by the ultrasound NO generation was investigated. As the results, we found that tumor vascular permeability temporarily increased at the same time as the NO generation in the inside of the tumor increased temporarily by the ultrasound irradiation.
|
