2013 Fiscal Year Final Research Report
Development of molecular-targeted bubbles based on clinically available ultrasound contrast agent
| Project/Area Number |
23700591
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Medical systems
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| Research Institution | National Cardiovascular Center Research Institute |
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Principal Investigator |
OTANI Kentaro 独立行政法人国立循環器病研究センター, 研究所, 研究員 (50470191)
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| Project Period (FY) |
2011 – 2013
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| Keywords | マイクロ・ナノデバイス / 生体分子 / 超音波 / 分子イメージング / 薬学 |
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| Research Abstract |
In the present study, we developed the preparation method of targeted-bubbles for ultrasound molecular imaging based on clinically available ultrasound contrast agent, Sonazoid. By modifying Sonazoid with lactadherin, the number of adhered bubbles to integrin avb3-expresssing endothelial cells was increased significantly. Our results would imply the feasibility of lactadherin-bearing Sonazoid as ultrasound contrast agent for angiogenesis. The future in vivo studies would be of benefit.
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