2013 Fiscal Year Final Research Report
Identification of functional molecules in stroke rehabilitation and pharmacotherapy for movement disorders
| Project/Area Number |
23700642
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Rehabilitation science/Welfare engineering
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| Research Institution | Fujita Health University |
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Principal Investigator |
MIZUTANI Kenmei 藤田保健衛生大学, 藤田記念七栗研究所, 講師 (30351068)
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| Project Period (FY) |
2011 – 2013
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| Keywords | 脳梗塞 / リハビリテーション / 薬物併用療法 / 神経可塑性 / 機能回復 |
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| Research Abstract |
It has become widely known that rehabilitation after stroke brings about some improvement of paralysis; however, not much is known about the detailed molecular pathway in the brain. Therefore, identification of molecules related to improvement of paralysis will contribute to establishing a new treatment strategy for stroke rehabilitation. First of all we examined protein expression changes in the cerebral cortex of rat groups with/without exercise after stroke. In the alteration of protein expression profile, NGF, calmodulin and PKC proteins were increased by exercise. Secondly we examined the effects of administration of an activator of PKC, combined with exercise on functional recovery after infarction. In behavioral evaluation using rotarod test, the combination of voluntary exercise and PKC activator administration induced further functional recovery compared with exercise alone, and the behavioral effect seen in administrated animals was dose-dependent.
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[Journal Article] Analysis of motor ataxia in relation to cerebellar morphology in the B6-wob/t mouse2013
Author(s)
Masanori Shinzato, Hidehiko Beppu, Kenmei Mizutani, Shigeru Sonoda, Toshihiko Katafuchi, Masataka Ifuku, Mami Hanada, Naoki Takayanagi, Kumiko Yamaguchi, Hiroyuki Nakagawa, Youzi Watanabe, Hisahide Takahashi
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Journal Title
Structure and Function
Volume: 12(1)
Pages: 10-19
Peer Reviewed
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[Presentation] 回復期リハビリテーション患者の入院および退院時 FIM運動評価に関連する血中遊離アミノ酸の検索2014
Author(s)
別府秀彦 ,岡崎英人 ,玉井育子 ,水谷謙明 ,尾関保則 ,井谷功典 ,富田豊,宮坂裕之 ,谷野元一 , Orand Abbas,千原猛 ,新保寛 ,園田茂
Organizer
第24回生物試料分析化科学会年次学術集会
Place of Presentation
三重鈴鹿
Year and Date
20140301-02
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