2012 Fiscal Year Final Research Report
The responses of tripartite motif-containing 72 to the changes in skeletal muscle mass of mice
| Project/Area Number |
23700647
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Rehabilitation science/Welfare engineering
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| Research Institution | Toyohashi Sozo University |
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Principal Investigator |
OHNO Yoshitaka 豊橋創造大学, 保健医療学部, 講師 (80440808)
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| Project Period (FY) |
2011 – 2012
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| Keywords | 細胞・組織 / ストレス / 筋肥大 / 筋萎縮 / 筋細胞膜 |
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| Research Abstract |
Protein expression levels of tripartite motif-containing 72 (TRIM72) in atrophied, regrown, and hypertrophied mouse soleus muscle were investigated. In unloading-associated atrophied muscle, the mean expression levels of TRIM72, phopsho-Akt (p-Akt) and phosho-p70S6K (p-p70S6K) were decreased. On the other hand, the increase in the expressions of TRIM72, p-Akt and p-p70S6K were observed during muscle regrowth of atrophied muscle. Although the expression levels of p-Akt and p-p70S6K were also increased in overloading-associated hypertrophied muscle, TRIM72 expression was stable. These observations strongly suggested that a role of TRIM72 might be different between hypertrophy and regrowth of skeletal muscle.
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Research Products
(15 results)
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[Journal Article] Adaptation of mouse skeletal muscle to long-term microgravity in the MDS mission2012
Author(s)
Sandona D, Desaphy JF, Camerino GM, Bianchini E, Ciciliot S, Danieli-Betto D, Dobrowolny G, Furlan S, Germinario E, Goto K, Gutsmann M, Kawano F, Nakai N, Ohira T, Ohno Y, Picard A, Salanova M, Schiffl G, Blottner D, Musaro A, Ohira Y, Betto R, Conte D, Schiaffino S
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Journal Title
PLoS ONE
Volume: 7(3)
Pages: e33232
DOI
Peer Reviewed
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[Journal Article] Some aspects of heat stress on the plasticity of skeletal muscle cells2012
Author(s)
K. Goto, Y. Ohno, A. Goto, A. Ikuta, M. Suzuki, T. Ohira, N. Tsuchiya, S. Nishizawa, T. Koya, T. Egawa, T. Sugiura, Y. Ohira and T. Yoshioka
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Journal Title
The Journal of Physical Fitness and Sports Medicine
Volume: 1(2)
Pages: 197-204
DOI
Peer Reviewed
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[Journal Article] Absence of heat shock transcription factor 1 retards the regrowth of atrophied soleus muscle in mice2011
Author(s)
Yasuhara K, Ohno Y, Kojima A, Uehara K, Beppu M, Sugiura T, Fujimoto M, Nakai A, Ohira Y, Yoshioka T, Goto K
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Journal Title
Journal of Applied Physiology
Volume: 111
Pages: 1142-1149
DOI
Peer Reviewed
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