2013 Fiscal Year Final Research Report
Oxidative stress in polio survivors and the patients with post-polio syndrome
| Project/Area Number |
23700655
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Rehabilitation science/Welfare engineering
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| Research Institution | University of Occupational and Environmental Health, Japan |
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Principal Investigator |
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| Project Period (FY) |
2011 – 2013
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| Keywords | ポリオ / ポリオ後症候群 / 酸化ストレス / 8-isoprostane / 8-hydroxydeoxyguanosine |
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| Research Abstract |
The purpose of this study was to investigate whether oxidative stress is etiology of post-polio syndrome (PPS) . We examined the oxidative stress markers for 27 polio survivors (mean age, 59.3 years) and 13 healthy controls (mean age, 58.0 years). Urinary 8-hydroxydeoxyguanosine (8-OHdG) concentrations were significantly increased with polio survivors as compared to healthy controls. Moreover, urinary 8-isoprostane concentrations were significantly increased with polio survivors with PPS as compared to polio survivors without PPS. These results indicate that the oxidative stress may be etiology of PPS and suggest that 8-isoprostane may provide a biological marker for predicting PPS.
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