2012 Fiscal Year Final Research Report
Identification of development and regulatory mechanisms of spasticity following spinal cord injury
| Project/Area Number |
23700659
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Rehabilitation science/Welfare engineering
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| Research Institution | National Rehabilitation Center for Persons with Disabilities |
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Principal Investigator |
MORIOKA Kazuhito 国立障害者リハビリテーションセンター(研究所), 研究所 運動機能系障害研究部, 客員研究員 (90551466)
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| Project Period (FY) |
2011 – 2012
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| Keywords | リハビリテーション / 脳・神経 / 動物 / 細胞・組織 |
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| Research Abstract |
To identify the mechanism how spasticity, appeared after spinal cord injury (SCI), impairs the recovery of locomotor function, we established the rodent model that develops symptoms of spastic behavior in hindlimb, and developed methods to evaluate spasticity and hyperreflexia. Our findings of a multidisciplinary analysis demonstrated that loss of paretic limb loading early after SCI induced irreversible inhibition of locomotor recovery relating to spasticity, and provided insight into mechanisms in the development of spasticity.
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Research Products
(7 results)
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[Journal Article] Phosphorylated neurofilament subunit NF-H as a biomarker for evaluating the severity of spinal cord injury patients2012
Author(s)
Hayakawa K, Okazaki R, Ishii K, Ueno T, Izawa N, Tanaka S, Toyooka S, Matsuoka N, Morioka K, Ohori Y, Nakamura K, Akai M, Tobimatsu Y, Hamabe Y, Ogata T
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Journal Title
a pilot study. Spinal Cord
Volume: 50(7)
Pages: 493-496
DOI
Peer Reviewed
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