2013 Fiscal Year Final Research Report
Importance of extracellular proteases in mediating exercise-induced promotion of hippocampal plasticity
| Project/Area Number |
23700775
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
|
| Allocation Type | Multi-year Fund |
|---|
| Research Field |
Sports science
|
|---|
| Research Institution | Tokyo Metropolitan University |
|---|
Principal Investigator |
|
|---|
| Project Period (FY) |
2011 – 2013
|
| Keywords | マトリックスメタロプロテイナーゼ / MMP-9 / 低強度運動 / 海馬 / 細胞外環境 |
|---|
| Research Abstract |
Matrix metaroproteinase-9 (MMP-9), an extracellular protease, plays a critical role in regulating neuronal function through remodeling of extracellular matrix. In this study, we have investigated whether MMP-9 is involved in exercise-induced promotion of hippocampal plasticity. We found that MMP-9 proteolytic activity in the rat hippocampus was increased at 12 h after a bout of treadmill running at mild intensity, which partially supports our hypothesis. Further studies are needed to examine whether inhibition of MMP-9 activity diminishes exercise-induced promotion of hippocampal plasticity, such as neurogenesis
|
