2012 Fiscal Year Final Research Report
Investigation on the preventive effect of the novel myokine Sparcon colon tumorigenesis
| Project/Area Number |
23700776
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Sports science
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| Research Institution | Kyoto Prefectural University |
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Principal Investigator |
AOI Wataru 京都府立大学, 大学院・生命環境科学研究科, 助教 (60405272)
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| Project Period (FY) |
2011 – 2012
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| Keywords | 骨格筋 / マイオカイン / タンパク質 / 大腸がん / 運動 |
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| Research Abstract |
We found a novel muscle-secreted protein, secreted protein acidic and rich in cysteine (SPARC). In this study, I have examined the preventive effect of the novel myokine SPARC on colon tumorigenesis using SPARC-null mouse. As a result, regular low-intensity exercise significantly reduced the formation of the precursor lesions of colon adenocarcinoma in wild-type mice, whereas exercise did not have an inhibitory effect. In addition, regular exercise increased apoptotic activity in the colon of wild-type mice; however, the activity did not differ between sedentary and exercised SPARC-null mice. These results suggest that the secreted-protein SPARC may suppress proliferation of colon tumor cells via increasing caspase activity.
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[Journal Article] A novel myokine, secreted protein acidic and rich in cysteine (SPARC), suppresses colon tumorigenesis via regular exercise2013
Author(s)
Aoi W, Naito Y, Takagi T, Tanimura T, Takanami Y, Kawai Y, Sakuma K, Hang LP, Mizushima K, Hirai Y, Koyama R, Wada S, Higashi A, Kokura S, Ichikawa H, and Yoshikawa T.
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Journal Title
Gut
Volume: 62
Pages: 882-889
Peer Reviewed
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[Journal Article] Dietary whey hydrolysate with exercise alters the plasma protein profile: A comprehensive protein analysis.2011
Author(s)
Aoi W, Takanami Y, Kawai Y, Morifuji M, Koga J, Kanegae M, Mihara K, Yanohara T, Mukai J, Naito Y, Yoshikawa T.
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Journal Title
Nutrition
Volume: 27
Pages: 687-692
Peer Reviewed
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