2013 Fiscal Year Final Research Report
Effect of exercise on gut immunity by the antibacterial peptide.
| Project/Area Number |
23700777
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Sports science
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| Research Institution | Kyoto Prefectural University of Medicine |
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Principal Investigator |
TANIMURA Yuko 京都府立医科大学, 医学(系)研究科(研究院), 助教 (90551458)
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| Project Period (FY) |
2011 – 2013
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| Keywords | 抗菌ペプチド / 腸管免疫 / 運動 |
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| Research Abstract |
Mouse Paneth cell defensins, termed cryptdins, plays a central role in innate immunity as a substance that is secreted into the intestinal tract. The purpose of this study was to examine the effects of acute exercise and chronic exercise on the cryptdin. In acute exercise, cryptdin was tended to increase with increasing inflammatory markers. On the other hand, DSS colitis in voluntary wheel running mice were increased both cryptdin and inflammatory markers. Consequently, we suggested that a change in cryptdin by exercise affects the inflammatory markers.
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