Association of genetic polymorphisms in hypertension related genes with an increased risk of cardiovascular disease in hypertensive patients

2013 Fiscal Year Final Research Report

• Project/Area Number: 23700815
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Applied health science
• Research Institution: Mukogawa Women's University Junior College Division
• Principal Investigator: BANNO Mariko 武庫川女子大学短期大学部, 食生活学科, 准教授 (90400530)
• Project Period (FY): 2011 – 2013
• Keywords: 高血圧 / 遺伝子多型 / 24時間血圧 / 血圧日内変動 / 慢性腎臓病 / 頸動脈肥厚

Research Abstract

Blood pressure (BP) variations, especially non-dipping patterns during sleep, are known to increase cardiovascular event risk in hypertensive patients. In this study, we examined the relationship between 185 single nucleotide polymorphisms (SNPs) in hypertension related genes and circadian variation of BP in Japanese hypertensives. We found that the SNPs in ACE2, ECE2, SCNN1A, SLC12A3, MOP4, PER2 and PER3 genes were significantly associated with the non-dipping pattern of BP in essential hypertensive patients. We also found the significant association between the SNPs in EDNRA and NCX1 genes and the prevalence of chronic kidney disease complication in hypertensives. The SNP in VWF gene was associated with the carotid intima-media thickness in hypertensives. Taken together, our results revealed that the genetic polymorphisms in ACE2, ECE2, SCNN1A, SLC12A3, MOP4, PER2, PER3, EDNRA, NCX1 and VWF genes could cause an increased risk of cardiovascular event in Japanese hypertensives.

Research Products

• [Journal Article] 都市部一般住民を対象とした大豆摂取の動脈硬化進展予防に関する追跡研究 (2013)
  • Author(s): 小久保喜弘、古川曜子、坂野麻里子
  • Journal Title: 大豆たん白研究 Volume: 16 Pages: 1-6
  • Peer Reviewed
• [Journal Article] 高ホモシステイン血症と心血管疾患について (2013)
  • Author(s): 坂野麻里子
  • Journal Title: 栄養兵庫 Volume: 219 Pages: 5
  • Peer Reviewed
• [Journal Article] Association of intima-media thickening of carotid artery with genetic polymorphisms of the regulator of G-protein signaling 2 gene in patients with hypertension and in the general population (2011)
  • Author(s): Kamide K, Kokubo Y, Yang J, Takiuchi S, Horio T, Matsumoto S, Banno M, Matayoshi T, Yasuda H, Miwa Y, Yoshihara F, Nakamura S, Nakahama H, Iwashima Y, Oguro R, Ohishi M, Rakugi H, Okamura T, Miyata T, Kawano Y
  • Journal Title: Hypertension Research Volume: 34 Pages: 740-746
  • Peer Reviewed
• [Presentation] 都市部一般住民を対象とする大豆摂取の動脈硬化進展予防に関する追跡研究 (2013)
  • Author(s): 小久保喜弘、古川曜子、坂野麻里子
  • Organizer: 大豆たん白研究報告会
  • Place of Presentation: 千里阪急ホテル(豊中市)
  • Year and Date: 2013-05-27
• [Presentation] 都市部一般住民を対象とするコーヒー摂取量と動脈硬化との関連に関する疫学研究吹田研究 (2011)
  • Author(s): 小久保喜弘、古川曜子、坂野麻里子
  • Organizer: 日本栄養改善学会学術総会第58回大会
  • Place of Presentation: 広島国際会議場(広島市)
  • Year and Date: 2011-09-07
• [Presentation] Genetic polymorphisms of endothelin-related genes associated with risk of chronic kidney disease in Japanese hypertensives (2011)
  • Author(s): Banno M, Kamide K, Horio T, Miyata T, Kawano Y
  • Organizer: The International Society on Thrombosis and Haemostasis XXIII Congress
  • Place of Presentation: Kyoto International Conference Center (Kyoto)
  • Year and Date: 2011-07-27
• [Presentation] THE ASSOCIATION BETWEEN PLASMA-FIBRINOGEN AND CORONARY HEART DISEASE IN A JAPANESE URBAN COHORT : THE SUITA STUDY (2011)
  • Author(s): Kokubo Y, Miyata T, Sakata T, Okamoto A, Watanabe M, Ono Y, Banno M, Miyamoto Y
  • Organizer: The International Society on Thrombosis and Haemostasis XXIII Congress
  • Place of Presentation: Kyoto International Conference Center (Kyoto)
  • Year and Date: 2011-07-26