2012 Fiscal Year Final Research Report
The effects of food protein-derived metabolite, indoxyl sulfate, on progression of renal disease.
Project/Area Number |
23700830
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Multi-year Fund |
Research Field |
Applied health science
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Research Institution | Hokkaido University (2012) Nagoya University (2011) |
Principal Investigator |
SHIMIZU Hidehisa 北海道大学, 大学院・農学研究院, 特任講師 (10547532)
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Project Period (FY) |
2011 – 2012
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Keywords | 慢性腎不全 / 尿毒症物質 / トリプトファン代謝物 / インドキシル硫酸 / 細胞老化 / 線維化 / 炎症反応 |
Research Abstract |
In patients with chronic kidney disease (CKD), serum indoxyl sulfate is elevated. Therefore, the present study examined what molecules are activated and expressed by indoxyl sulfate, and how indoxyl sulfate promotes CKD. Indoxyl sulfate activated ERK, p38, JNK, NF-?B, p53, Stat3, and CREB in proximal tubular cells. In addition, the expression of NOX4, TGF-?1, Smad3, ?-SMA, MCP-1, ICAM-1, and angiotensinogen was upregulated. Current study demonstrated that indoxyl sulfate induced macrophage infiltration, cellular senescence, and fibrosis through activation and expression of above-mentioned factors in process of CKD progression.
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Research Products
(22 results)
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[Journal Article] Effects of environmental lead contamination on cattle in a lead/zinc mining area: changes in cattle immune systems on exposure to lead in vivo and in vitro.2012
Author(s)
Ikenaka Y, Nakayama SMM, Muroya T, Yabe J, Konnai S, Darwish WS, Muzandu K, Choongo K, Mainda G, Teraoka H, Umemura T, Ishizuka M.
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Journal Title
Environ Toxicol Chem
Volume: 31(10)
Pages: 2300-5
Peer Reviewed
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[Journal Article] Transcriptional profiling of inflammatory cytokine genes in African buffaloes (Syncerus caffer) infected with Theileria parva.2012
Author(s)
Okagawa T, Konnai S, Mekata H, Githaka N, Suzuki S, Kariuki E, Gakuya F, Kanduma E, Shirai T, Ikebuchi R, Ikenaka Y, Ishizuka M, Murata S, Ohashi K.
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Journal Title
Vet Immunol Immunopathol
Volume: 148(3-4)
Pages: 373-9
Peer Reviewed
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[Journal Article] Molecular cloning and characterization of Th1 and Th2 cytokines of African buffalo (Syncerus caffer).2012
Author(s)
Suzuki S, Konnai S, Okagawa T, Githaka NW, Kariuki E, Gakuya F, Kanduma E, Shirai T, Ikebuchi R, Ikenaka Y, Ishizuka M, Murata S, Ohashi K.
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Journal Title
Int J Immunogenet
Pages: 170-82
Peer Reviewed
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