2012 Fiscal Year Final Research Report

Macrophages are associated with exercise-induced increase in insulin sensitivity

Research Project

Project/Area Number	23700842
Research Category	Grant-in-Aid for Young Scientists (B)
Allocation Type	Multi-year Fund
Research Field	Applied health science
Research Institution	Juntendo University
Principal Investigator	IKEDA Shin-ichi 順天堂大学, 医学研究科, 博士研究員 (50534898)
Project Period (FY)	2011 – 2012
Keywords	運動 / インスリン感受性 / マクロファージ
Research Abstract	Exercise is a powerful tool to enhance insulin sensitivity in skeletal muscle, however, the precise mechanisms are largely unknown. We hypothesized that macrophages, especially anti-inflammatory M 2 macrophages, are associated with increase in muscle insulin sensitivity after exercise. A single bout of treadmill running increased number of M2 macrophages in skeletal muscle in PBS-ex group. On the other hand, in CL-ex group, number of M2 macrophages were not increased after exercise. Concomitant with change of M2 macrophages, insulin-stimulated 2-DG uptake was increased 24 h after a single bout of exercise in PBS-ex group, however, CL-ex group were not. From these results,we concluded that M2 macrophages are involved in exercise-induced increase in muscle insulin sensitivity.