2013 Fiscal Year Final Research Report
The effect of exercise and diosgenin induced increase of sex steroid hormone on type 2 diabetes
| Project/Area Number |
23700849
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Applied health science
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| Research Institution | Ritsumeikan University |
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Principal Investigator |
SATO Koji 立命館大学, スポーツ健康科学部, 助教 (20584022)
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| Project Period (FY) |
2011 – 2013
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| Keywords | 性ステロイドホルモン / 糖尿病 / 骨格筋 / 糖代謝 |
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| Research Abstract |
In study 1, acute dehydroepiandrosterone (DHEA) administration improves hyperglycemia in rats with streptozotocin (STZ)-induced type 1 diabetes mellitus. Diosgenin, a steroid structurally similar to DHEA (dehydroepiandrosterone), however, it is still unclear whether diosgeninimproves hyperglycemia in the type 1 diabetes model rats through an increase muscular GLUT4 signaling. As a result, diosgenin injections decreased blood glucose level. Moreover, GLUT4 translocation, as well as phosphorylation of Akt and PKC, increased significantly by diosgenin or dioscorea administration.
In study 2, we determined whether chronic diosgenin administration improve insulin resistance in type 2 diabetes model rat. 8-week diosgenin administration significantly improved fasting blood glucose level and insulin resistance. Accordingly, diosgenin administration may be possible new therapetic candidates for type 1 and 2 diabetes.
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Research Products
(27 results)
