2012 Fiscal Year Final Research Report
Evaluation of spices according to suppression of COX-2 and activation of PPAR
| Project/Area Number |
23700905
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Eating habits, studies on eating habits
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| Research Institution | Tezukayama Gakuin University |
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Principal Investigator |
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| Project Period (FY) |
2011 – 2012
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| Keywords | 誘導型シクロオキシゲナーゼ / PPAR / 香辛料 / 食品機能成分 / 生活習慣病予防 |
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| Research Abstract |
Spice essential oils derived from cinnamon bark, caraway seed, cinnamon leaf, cumin and cardamom suppressed COX-2 expression and activated PPARs in cell-based reporter assays. Moreover, trans-cinnamaldehyde, a major component of cinnamon bark, activated PPARα,ss/δ and γ, and suppressed COX-2 expression by PPARγ-dependent manner.
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