2012 Fiscal Year Final Research Report

Molecular mechanisms of the protective effects against memory impairment of rutin

Research Project

Project/Area Number	23700927
Research Category	Grant-in-Aid for Young Scientists (B)
Allocation Type	Multi-year Fund
Research Field	Eating habits, studies on eating habits
Research Institution	Tokyo Health Care University
Principal Investigator	KODA Tomoko 東京医療保健大学, 看護学部, 講師 (30391098)
Project Period (FY)	2011 – 2012
Keywords	健康と食生活 / ルチン / 記憶 / 神経回路 / AMPA型受容体
Research Abstract	Various phytochemical constituents have been widely investigated owing to their beneficial effects on health, especially on memory function. We have examined that the effects of some flavonoids (rutin, quercetin and resveratrol) on AMPA receptor trafficking to plasma membrane of hippocampal neurons and neurite outgrowth using PC12 cells. Resveratrol has tended to induce AMPA receptor trafficking to plasma membrane, however rutin and quercetin did not have that effect. On the other hand, rutin and quercetin have tended to induce the neurite outgrowth of PC12 cells, however resveratrol did not effect on neurite outgrowth. Each flavonoid may havespecifically molecular mechanisms of memory function.