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2013 Fiscal Year Final Research Report

Development of nutrition treatment for improving crosstalk change of blood vessel - skeletal muscle in musculoskeletal system.

Research Project

  • PDF
Project/Area Number 23700932
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Eating habits, studies on eating habits
Research InstitutionNagoya Women's University

Principal Investigator

KONDO HIROYO  名古屋女子大学, 家政学部, 准教授 (50333183)

Project Period (FY) 2011 – 2012
Keywords骨格筋 / サルコペニア / 血管 / 糖尿病 / 栄養
Research Abstract

Identification of nutrients with significant cross-talk between muscle and vessel potential useful for the development of preventive therapy in sarcopenia has gained increasing importance. Therefore, the aim of this study was investigated the cross-talk between muscle fiber and capillary potential of nutrients against myoblasts and pathological animal models. Several nutrients such as plant and animal food derived extracts showed high proliferation potency in myoblasts. In addition, these nutrients were administrated orally to the rats of muscle atrophy. As expected, the nutrients of dairy product extracts, antioxidants, and hyperamino acids attenuated the muscle atrophy and maintained the capillary networks, and oxdative stress levels. These results indicate that nutrients could be an effective therapy for both the muscle and capillary associated with a chronic decrease in neuromuscular activity and/or diabetes.

  • Research Products

    (22 results)

All 2014 2013 2012 2011

All Journal Article (6 results) Presentation (14 results) Book (2 results)

  • [Journal Article] Protective Effects of Astaxanthin on Capillary Regression in Atrophied Soleus Muscle of Rats2013

    • Author(s)
      Kanazashi M, Okumura Y, Al-Nassan S, Murakami S, Kondo H, Nagatomo F, Fujita N, Ishihara A, Roy RR, Fujino H
    • Journal Title

      Acta Physiol

      Volume: 207 Pages: 405-415

  • [Journal Article] Differential Effects of Astaxanthin on Oxidative Key Enzyme and Capillarization in the Deep and Superficial Layers of Unloading-induced Atrophied Muscle2013

    • Author(s)
      Okumura Y, Kanazashi M, Kanazawa Y, Fujita N, Kondo H, Fujino H
    • Journal Title

      J Phys Ther Sci

      Volume: 25 Pages: 349-353

  • [Journal Article] Decreased Succinate Dehydrogenase Activity of Gamma and Alpha Motoneurons in Mouse Spinal Cords Following 13 Weeks of Exposure to Microgravity2013

    • Author(s)
      Ishihara A, Nagatomo F, Fujino H, Kondo H, Ohira Y
    • Journal Title

      Neurochemical Research

      Volume: 38 Pages: 2160-2167

  • [Journal Article] High-fat diet-induced reduction of peroxisome proliferator -activated receptor -γ coactivator -1αmessenger RNA levels and oxidative capacity in the soleus muscle of rats with metabolic syndrome2012

    • Author(s)
      Nagatomo F, Fujino H, Kondo H, Takeda I, Tsuda K, Ishihara A
    • Journal Title

      Nutr Res

      Volume: 32 Pages: 144-151

  • [Journal Article] Regressed three-dimensional capillary network and inhibited angiogenic factors in the soleus muscle of non-obese rats with type 2 diabetes2011

    • Author(s)
      Kondo H, Fujino H, Murakami S, Nagatomo F, Roy RR, Ishihara A
    • Journal Title

      Nutr Metab

      Volume: 8 Pages: 6pages

  • [Journal Article] Lifestyle-related disease and skeletal muscle : A review2011

    • Author(s)
      Ishihara A, Nagatomo F, Fujino H, Kondo H, Tsuda K
    • Journal Title

      J Phys Fitness Sports Med

      Volume: 1 Pages: 1-11

  • [Presentation] Astaxanthin attenuates lipopolysaccharide -induced atrogin-1 expression in C2C12 myotubes2014

    • Author(s)
      Takegaki J, Kondo H, Fujino H
    • Organizer
      Experimental Biology
    • Place of Presentation
      San Diego, USA
    • Year and Date
      20140400
  • [Presentation] Relation of genetic polymorphisms and nutrient with bone density and skeletal muscle mass in Japanese young women2014

    • Author(s)
      Kondo H, Fujino, Nagatomo F, Ishihara A
    • Organizer
      Experimental Biology
    • Place of Presentation
      San Diego, USA
    • Year and Date
      20140400
  • [Presentation] Astaxanthin Protects Oxidative Stress and Metabolic Disorders of Atrophied Soleus Muscle in Rats2013

    • Author(s)
      Kanazashi M, Tanaka M, Tanaka M, Hirayama Y, Nagatomo F, Fujita N, Kondo H, Murakami S, Ishihara A, Fujino H
    • Organizer
      34th Annual Meeting International Gravitational Physiology
    • Place of Presentation
      Toyohashi, JAPAN
    • Year and Date
      20130600
  • [Presentation] Effects of exercise training of different intensities on capillary network in skeletal muscle with nonobese type 2 diabetes2013

    • Author(s)
      Fujino H, Kondo H, Murakami S, Tanaka M, Nagatomo F, Ishihara A
    • Organizer
      American College of Sports Medicine
    • Place of Presentation
      Indianapolis, USA
    • Year and Date
      20130500
  • [Presentation] Treadmill running improves diabetes-induced capillary regression in skeletal muscle through activation of VEGF and angiopoietin pathways without inhibition of thrombospondin-12013

    • Author(s)
      Fujino H, Kondo H, Murakami S, Tanaka M, Fujita N, Nagatomo F, Ishihara A
    • Organizer
      Experimental Biology
    • Place of Presentation
      Boston, USA
    • Year and Date
      20130400
  • [Presentation] Beneficial effect of exercise combined with licorice flavonoid oil supplementation on visceral adipose tissue2013

    • Author(s)
      Tanaka M, Kanazashi M, Tanaka M, Kondo H, Murakami S, Fujita N, Fujino H
    • Organizer
      Experimental Biology
    • Place of Presentation
      Boston, USA
    • Year and Date
      20130400
  • [Presentation] Protective effects of loading combined with astaxanthin on capillary regression of disused muscle2013

    • Author(s)
      Kanazashi M, Tanaka M, Tanaka M, Kondo H, Murakami S, Fujita N, Fujino H
    • Organizer
      Experimental Biology
    • Place of Presentation
      Boston, USA
    • Year and Date
      20130400
  • [Presentation] Comparison of rectangular and sine waveforms on electrical stimulation to atrophy of rat soleus muscle2013

    • Author(s)
      Tanaka M, Tanaka M, Kanazashi M, Kondo H, Murakami S, Fujita N, Fujino H
    • Organizer
      Experimental Biology
    • Place of Presentation
      Boston, USA
    • Year and Date
      20130400
  • [Presentation] Vitamin D receptor and Estrogen receptor alpha Genotype affects Exercise related Bone mass in Japanese healthy women2013

    • Author(s)
      Kondo H, Fujino H, Murakami S, Fujita N, Nagatomo F, Ishihara A
    • Organizer
      Experimental Biology
    • Place of Presentation
      Boston, USA
    • Year and Date
      20130400
  • [Presentation] Ameliorative effects of antioxidant astaxanthin on capillary regression in hindlimb unloading-induced atrophied muscle2012

    • Author(s)
      Fujino H, Kanazashi M, Kondo H, Murakami S, Nagatomo F, Fujita N, Ishihara A
    • Organizer
      Integrative Biology of Exercise VI
    • Place of Presentation
      Colorado, USA
    • Year and Date
      20121000
  • [Presentation] Reduction In Muscle Capillary Is Inversely Associated With Vegf Expression In Non-obese Type 2 Diabetic Rats2012

    • Author(s)
      Kondo H, Fujino H, Murakami S, Nagatomo F, Fujita N, Ishihara A
    • Organizer
      59th American College of Sports Medicine
    • Place of Presentation
      San Fransisco, USA
    • Year and Date
      20120500
  • [Presentation] Effects of exercise training on adipokines and glucose tolerance in non-obese spontaneously type 2 diabetic torii rats2012

    • Author(s)
      Kondo H, Fujino H, Murakami S, Nagatomo F, Morifuji T, Fujita N, Tanaka M, Ishihara A
    • Organizer
      Experimental Biology 2012
    • Place of Presentation
      San Diego, USA
    • Year and Date
      20120400
  • [Presentation] Three-dimensional microcirculatory measurements and the protective effects of endurance exercise on its complications in non-obese type 2 diabetic muscle2011

    • Author(s)
      Kondo H, Fujino H, Murakami S, Nagatomo F, Fujita N, Ishihara A
    • Organizer
      American society for cell biology
    • Place of Presentation
      Denver, USA
    • Year and Date
      20111200
  • [Presentation] Three-dimensional visualization of capillary and prevention of capillary regression by antioxidant supplementation in disused skeletal muscle2011

    • Author(s)
      Fujino H, Kanazashi M, Kondo H, Murakami S, Nagatomo F, Fujita N, Ishihara A
    • Organizer
      American society for cell biology
    • Place of Presentation
      Denver , USA
    • Year and Date
      20111200
  • [Book] カレント社会・環境と健康公衆衛生学2014

    • Author(s)
      近藤浩代, 他
    • Total Pages
      194
    • Publisher
      建帛者
  • [Book] 公衆衛生学実験・実習2011

    • Author(s)
      近藤浩代, 他
    • Total Pages
      152
    • Publisher
      建帛者

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Published: 2015-06-25  

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