2012 Fiscal Year Final Research Report
Effects of maternal nutrition for essential metals on placental leptin expression
| Project/Area Number |
23700933
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Eating habits, studies on eating habits
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| Research Institution | Osaka Ohtani University |
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Principal Investigator |
UEDA Hidenori 大阪大谷大学, 薬学部, 助教 (50419462)
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| Project Period (FY) |
2011 – 2012
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| Keywords | 必須金属 / レプチン / 胎盤 / 妊娠 |
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| Research Abstract |
Effects of maternal deficiency and overload of essential metals on placental leptin expression were studied in pregnant mice and human placental choriocarcinoma cell line JEG-3. The levels of plasma leptin and leptin receptor expression were decreased in essential metals deficient mice and increased in them overloaded mice. These results suggest that placenta-derived leptin and its receptor expression may be controlled by maternal nutrition of essential metals for fetal development.
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