2012 Fiscal Year Final Research Report
Analysis of phospholipid metabolic enzymes in thyroid tumors
| Project/Area Number |
23701036
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Carcinogenesis
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| Research Institution | Akita University |
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Principal Investigator |
KOFUJI Satoshi 秋田大学, 大学院・医学系研究科, 教育系補佐員 (00508153)
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| Project Period (FY) |
2010 – 2012
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| Keywords | リン脂質 |
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| Research Abstract |
Phosphatidylinositols are one of the important lipids composed of cell membranes, and there are eight species. Their abundance is very little, but they function as a signal molecule, and the dysfunction of the production or degradation of each species causes critical diseases, so they have been extensively researched. In this study, we analyzed the physiological roles by creating knockout mice for their enzymes. We found that the enzymes had an important role in thyroid tumors.
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Research Products
(3 results)
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[Journal Article] Critical roles of type III phosphatidylinositol phosphate kinase in murine embryonic visceral endoderm and adult intestine2013
Author(s)
Takasuga S, Horie Y, Sasaki J, Sun-Wada GH, Kawamura N, Iizuka R, Mizuno K, Eguchi S, Kofuji S, Kimura H, Yamazaki M, Horie C, Odanaga E, Sato Y, Chida S, Kontani K, Harada A, Katada T, Suzuki A, Wada Y, Ohnishi H, Sasaki T
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Journal Title
Proc Natl Acad Sci U S A.
Volume: 110(5)
Pages: 1726-31
DOI
Peer Reviewed
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