2012 Fiscal Year Final Research Report
Elucidation of the molecular mechanisms by which endothelial cells transdifferentiate into mesenchymal cells
| Project/Area Number |
23701045
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Tumor biology
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| Research Institution | The University of Tokyo |
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Principal Investigator |
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| Project Period (FY) |
2011 – 2012
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| Keywords | 血管内皮細胞 / がん関連線維芽細胞 / 内皮間葉分化転換 / TGF-ss |
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| Research Abstract |
Endothelial-mesenchymal transition (EndMT) in which endothelial cells transdifferentiate into mesenchymal cells has been implicated in the malignant phenotypes of heart diseases and tumorigenesis in the human body. In this study, we elucidated the molecular mechanisms by which endothelial cells undergo EndMT. As a molecular mechanism for EndMT, we found that TGF-β, a representative EndMT-inducing cytokine, induces the expression of the mesenchymal marker Smooth Muscle Alpha-Actin through inducing the expression and the nuclear translocation of the transcription factor MRTF-A during EndMT in MS-1 endothelial cells.
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