2012 Fiscal Year Final Research Report
Toward understanding of the lipid raft-based Src regulatory system
| Project/Area Number |
23701056
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Tumor biology
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| Research Institution | Osaka University |
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Principal Investigator |
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| Project Period (FY) |
2011 – 2012
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| Keywords | がん化 / Src / 脂質ラフト / スフィンゴ脂質 |
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| Research Abstract |
The proto-oncogene product c-Src is highly upregulated in various cancer cells. Src function is downregulated in the lipid rafts, indicating the lipid rafts serve as a negative regulator of activated c-Src. However, it has not been known how lipid rafts are altered during c-Src-induced cancer progression. In this study, we newly revealed that raft-localization of c-Src is regulated by lipid metabolism and that inhibition of lipid alteration suppresses c-Src-induced cell transformation. Taken together, Src regulates raft integrity by alteration of lipid metabolism for maintaining c-Src activation.
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