2012 Fiscal Year Final Research Report
NDRG2 inactivation and PI3K/Akt pathway activation in cancers
| Project/Area Number |
23701061
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Tumor biology
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| Research Institution | University of Miyazaki |
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Principal Investigator |
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| Project Period (FY) |
2011 – 2012
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| Keywords | NDRG2 / PTEN / PI3K/Akt / がん |
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| Research Abstract |
This study showed that PTEN is highly phosphorylated in a varietyof cancers and restoring expression of NDRG2 suppresses phosphorylation of PTEN and Akt.We also demonstrate for the first time that NDRG2 acts as a tumor suppressor. These resultscould contribute to the development of new drug targeting PTEN phosphorylation anddephosphorylation.
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