2014 Fiscal Year Final Research Report
CD133-responsive conditionally replicating adenovirus targeting cancer stem cells
| Project/Area Number |
23701062
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Tumor biology
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| Research Institution | Kagoshima University |
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Principal Investigator |
WANG Yuqing 鹿児島大学, 医歯(薬)学総合研究科, 特任研究員 (20505143)
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| Project Period (FY) |
2011-04-28 – 2015-03-31
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| Keywords | 腫瘍生物学 / 癌幹細胞 / 遺伝子治療 / アデノウイルス |
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| Outline of Final Research Achievements |
Cancer stem cells has been note as an important therapeutic target in cancer, and gene therapy such as by virotherapy focused on cancer stem cell maybe provides a novel therapeutic approach to anticancer. CD133 is known as a cancer stem marker expressed in nervous system tumors, colon cancer and prostate cancer, etc. A novel conditionally replicating adenovirus vector CD133pr.m-CRA was constructed and showed cancer stem cell-specific therapy effect in vitro and in vivo tumor model without toxicity to normal cells. Our date indicate that CD133.m-CRAs is a useful strategy for treating cancer stem cells.
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| Free Research Field |
総合生物
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