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2012 Fiscal Year Final Research Report

Characterization of the unfolded protein response (UPR) modulatorsin solid tumor microenvironment

Research Project

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Project/Area Number 23701067
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Tumor biology
Research InstitutionKyoto University

Principal Investigator

SAITO Sakae  京都大学, 医学(系)研究科(研究院), 研究員 (20335491)

Project Period (FY) 2011 – 2012
Keywords腫瘍微小環境 / 小胞体ストレス
Research Abstract

Solid tumors have regions of hypoxia and glucose deprivation, in which cancer cells activate the unfolded protein response (UPR). The UPR in cancer cells plays an important role in their survival under stress conditions, and thus the UPR is a potential target of antitumor therapy. Several UPR inhibitors are shown to exert antitumor activity in vivo. However, the effect of the UPR inhibitors on tumor microenvironment is not fully understood. We show that the UPR inhibitors suppress the gene expression both in cancer cells and in macrophages under hypoxic conditions.

  • Research Products

    (4 results)

All 2013 2012 2011

All Journal Article (2 results) (of which Peer Reviewed: 2 results) Presentation (2 results)

  • [Journal Article] Development of a gene expression database and related analysis programs for evaluation of anticancer compounds.2013

    • Author(s)
      Masaru Ushijima, Tetsuo Mashima, Akihiro Tomida, Shingo Dan, Sakae Saito, Aki Furuno, Satomi Tsukahara, Hiroyuki Seimiya, Takao Yamori, Masaaki Matsuura
    • Journal Title

      Cancer Science

      Volume: 104 Pages: 360-368

    • DOI

      DOI:10.1111/cas.12071

    • Peer Reviewed
  • [Journal Article] Compound C prevents the unfolded protein response during glucose deprivation through a mechanism independent of AMPK and BMP signaling2012

    • Author(s)
      Sakae Saito, Aki Furuno, Junko Sakurai, Hae-Ryong Park, Kazuo Shin-Ya, Akihiro Tomida
    • Journal Title

      PLoS One

      Volume: 7

    • DOI

      DOI:10.1371/journal.pone.0045845

    • Peer Reviewed
  • [Presentation] Dorsomorphin はグルコース飢餓により誘導される小胞体ストレス応答を阻害する2011

    • Author(s)
      齋藤さかえ、新家一男、冨田章弘
    • Organizer
      第70回日本癌学会学術総会
    • Place of Presentation
      名古屋
    • Year and Date
      2011-10-05
  • [Presentation] グルコース飢餓環境下における小胞体ストレス応答(UPR)制御薬剤の作用機序の解析2011

    • Author(s)
      齋藤さかえ、芳賀直実、築茂由則、新家一男、冨田章弘
    • Organizer
      第15回日本がん分子標的治療学会学術集会
    • Place of Presentation
      東京
    • Year and Date
      2011-06-24

URL: 

Published: 2014-09-25  

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