2012 Fiscal Year Final Research Report
Functional analysis of phosphoinositides in invasion and metastasis of breast cancer cells
Project/Area Number |
23701069
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Multi-year Fund |
Research Field |
Tumor biology
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Research Institution | National Cancer Center Japan |
Principal Investigator |
YAMAGUCHI Hideki 独立行政法人国立がん研究センター, 研究所, ユニット長 (10345035)
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Project Period (FY) |
2011 – 2012
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Keywords | 浸潤 |
Research Abstract |
Invadopodia are membrane protrusions formed by invasive cancer cells that mediate degradation of pericellular ECM and have been implicated in local invasion during cancer metastasis. In this study, we investigated the role of phosphoinositide metabolism in invadopodium formation. We found that PI3 kinase p110α, a frequently mutated gene product in human cancers, is involved in invadopodium formation and invasion by breast cancer cells. This finding suggests that the signaling pathway via p110α is a potential therapeutic target for the treatment of cancer invasion and metastasis.
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[Journal Article] Epidermal loss of phospholipase C δ1 results in myeloproliferation in mice.2012
Author(s)
Kanemaru K, Nakamura Y, Sato K, Takahashi S, Yamaguchi M, Ichinohe M, Kiyonari H, Shioi G, Asagiri M, Jamora C, Kouchi Z, Yamaguchi H, and Fukami K
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Journal Title
Nature Commun
Volume: 3
Pages: 963
DOI
Peer Reviewed
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