2013 Fiscal Year Final Research Report
Involvement of soluble CD155 in cancer immune escape
| Project/Area Number |
23701072
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
|
| Allocation Type | Multi-year Fund |
|---|
| Research Field |
Tumor immunology
|
|---|
| Research Institution | University of Tsukuba |
|---|
Principal Investigator |
IGUCHI Akiko (間中 研子) 筑波大学, 医学医療系, 講師 (50575644)
|
|---|
| Project Period (FY) |
2011-04-28 – 2013-03-31
|
| Keywords | 細胞免疫 / 免疫逃避 |
|---|
| Research Abstract |
Mouse CD155 has only a membrane-bound form, but human CD155 has also soluble splice isoforms (sCD155) lacking the transmembrane region. Here, we show that cancer patients showed significantly higher concentration of sCD155 in the sera than healthy donors. To analyze the functional role of sCD155 in tumor immunity, we established MethA transfectant expressing sCD155. Mice inoculated with MethA transfectant expressing sCD155 showed increased tumor development and shorter survival, compared with mice inoculated with mock transfectant. These results suggest that sCD155 is involved in cancer immune escape in human.
|
