2013 Fiscal Year Final Research Report
Regulation of anti-tumor immunity by targeting cyclooxygenase-2 expressing cells
| Project/Area Number |
23701076
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Tumor immunology
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| Research Institution | Kyoto University (2012-2013)
Kitasato University (2011) |
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Principal Investigator |
INOUE Joe 京都大学, 医学(系)研究科(研究院), 助教 (00433714)
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| Project Period (FY) |
2011 – 2012
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| Keywords | cox-2 / tumor / dendritic cell / liposome |
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| Research Abstract |
The immunosuppression in tumor tissue has been attributed to tumor cells expressing cyclooxygenase (COX) -2. From this study, COX-2 was also expressed in tumor infiltrated CD11c+ cells. It was shown that through the production of immunosuppressive cytokines by COX-2+CD11c+ cells, the cells are largely responsible for immunosuppression in tumor tissues. Moreover, liposome (COX-2 selective inhibitors encapsulated liposome) which newly prepared to target the COX-2+CD11c+ cells, it showed the possibility to improve the immunosuppression by COX-2+CD11c + cells in tumor tissues.
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