2012 Fiscal Year Final Research Report
To identify the role of microRNA as a tumor suppressor in hematological malignancy
| Project/Area Number |
23701080
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Tumor diagnosis
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| Research Institution | Akita University |
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Principal Investigator |
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| Project Period (FY) |
2011 – 2012
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| Keywords | MicroRNA / 造血器腫瘍 / 悪性リンパ腫 / Mir-150 / 細胞老化 |
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| Research Abstract |
We analyzed aberrant expression of microRNAs in hematological malignancies. The levels of miR-150 expression in several lymphoma cell lines and clinical samples are significantly lower than in normal NK cells. We also found that miR-150 directly downregulates the expression of DKC1 and AKT2. These results suggest that miR-150 works as a tumor suppressor, and leading to telomerase activation. These findings provide new insight into the pathogenesis of malignant lymphoma.
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Research Products
(4 results)
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[Journal Article] The role of microRNA -150 as a tumor suppressor in malignant lymphoma2011
Author(s)
Watanabe A, Tagawa H, Yamashita J, Teshima K, Nara M, Iwamoto K, Kume M, Kameoka Y, Takahashi N, Nakagawa T, Shimizu N, Sawada K.
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Journal Title
Leukemia
Volume: 25(8)
Pages: 1324-1234
DOI
Peer Reviewed
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