2012 Fiscal Year Final Research Report
Quantitative proteome profiling to identify biomarkers and therapeutic targets for adult T-cell leukemia (ATL).
| Project/Area Number |
23701090
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Tumor diagnosis
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| Research Institution | The Institute of Physical and Chemical Research |
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Principal Investigator |
ISHIHARA Makoto 独立行政法人理化学研究所, バイオマーカー探索・開発チーム, 特別研究員 (60581189)
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| Project Period (FY) |
2011 – 2012
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| Keywords | プロテオミクス / 質量分析 / ATL / HTLV-1 / 機械学習 |
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| Research Abstract |
ATL is one of the most aggressive hematologic malignancies caused by human T-lymphotropic virus type 1 (HTLV-1) infection. The prognosis of ATL is extremely poor; however, effective strategies for diagnosis and treatment have not been established. 2-step statistical analysis for 14,064 peptides detected through focused proteomic profiling of the HTLV-1 enriched CD4^+CD25^+CCR4^+ T-cell subpopulation on 29 clinical cases were performed. 91 peptide determinants that statistically classified 4 clinical groups with an accuracy rate of 92.2% by cross-validation test were extracted, resulting in the identification of 17 classifier proteins which were potential diagnostic biomarkers and an attractive resource of therapeutic targets for ATL.
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