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2013 Fiscal Year Final Research Report

Novel multi-omics approach for discovery of splicing variants in cancer stem cells

Research Project

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Project/Area Number 23701092
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Tumor diagnosis
Research InstitutionShizuoka Cancer Center Research Institute

Principal Investigator

HATAKEYAMA Keiichi  静岡県立静岡がんセンター(研究所), その他部局等, 研究員 (20564157)

Project Period (FY) 2011 – 2012
Keywords癌 / バイオマーカー / オミクス / がん幹細胞 / スプライシング
Research Abstract

This research aim is development of novel multi-omics approach for discovery of splicing variants in cancer stem cells. Our approach is based on transcriptomics and proteomics. Using the multi-omics analysis, we identified novel cancer-specific aberrant transcripts (splice variants) and variant-derived proteins (protein isoforms) in cancer cells and patients with cancer.

  • Research Products

    (18 results)

All 2014 2013 2012 2011

All Journal Article (4 results) (of which Peer Reviewed: 4 results) Presentation (10 results) Patent(Industrial Property Rights) (4 results)

  • [Journal Article] Novel protein isoforms of carcinoembryonic antigen are secreted from pancreatic, gastric and colorectal cancer cells2013

    • Author(s)
      Keiichi Hatakeyama, Kanako Wakabayashi-Nakao, Keiichi Ohshima, Naoki Sakura, Ken Yamaguchi and Tohru Mochizuki
    • Journal Title

      BMC Research Notes

      Volume: 6 Pages: 381-90

    • DOI

      10.1186/1756-0500-6-381

    • Peer Reviewed
  • [Journal Article] Placenta-specific novel splice variants of Rho GDP dissociation inhibitor beta are highly expressed in cancerous cells2012

    • Author(s)
      Keiichi Hatakeyama, Yorikane Fukuda, Keiichi Ohshima, Masanori Terashima, Ken Yamaguchi and Tohru Mochizuki
    • Journal Title

      BMC Research Notes

      Volume: 5 Pages: 666-73

    • DOI

      10.1186/1756-0500-5-666

    • Peer Reviewed
  • [Journal Article] Novel protein extraction approach using micro-sized chamber for evaluation of proteins eluted from formalin-fixed paraffin-embedded tissue sections2012

    • Author(s)
      Keiichi Hatakeyama, Kanako Wakabayashi-Nakao, Yutaka Aoki, Shun-ichiro Ogura, Ken Yamaguchi, Takashi Nakajima, Taka-Aki Sato, Tohru Mochizuki and Isamu Hayashi
    • Journal Title

      Proteome Science

      Volume: 10 Pages: 19-25

    • DOI

      10.1186/1477-5956-10-19

    • Peer Reviewed
  • [Journal Article] Identification of a novel protein isoform derived from cancer-related splicing variants using combined analysis of transcriptome and proteome2011

    • Author(s)
      Keiichi Hatakeyama, Keiichi Ohshima, Yorikane Fukuda, Shun-ichiro Ogura, Masanori Terashima, Ken Yamaguchi and Tohru Mochizuki
    • Journal Title

      Proteomics

      Volume: 11 Pages: 2275-82

    • DOI

      10.1002/pmic.201100016

    • Peer Reviewed
  • [Presentation] Survivin expression in circulating tumor cells of patients with gastric cancer2014

    • Author(s)
      Masanori Terashima, Keiichi Hatakeyama, Yushi Yamakawa, Norihiko Sugisawa, Yuichiro Miki, Rie Makuuchi, Hironobu Goto, Masanori Tokunaga, Yutaka Tanizawa, Etsuro Bando, Taiichi Kawamura, Keiichi Oshima and Toru Mochizuki
    • Organizer
      2014 ASCO Gastrointestinal Cancers Symposium
    • Place of Presentation
      San Francisco, CA
    • Year and Date
      20140100
  • [Presentation] Identification of novel protein isoforms in secretome using combined analysis of microarray and massspectrometry2013

    • Author(s)
      Keiichi Hatakeyama, Keiichi Ohshima, Kanako Wakabayashi-Nakao, Yutaka Tanizawa, Masanori Terashima, Ken Yamaguchi and Tohru Mochizuki
    • Organizer
      第72回日本癌学会学術総会
    • Place of Presentation
      神奈川県,パシフィコ横浜
    • Year and Date
      20131000
  • [Presentation] Identification of the novel CEACAM5 protein isoforms ingastrointestinal cancer cells2013

    • Author(s)
      Kanako Nakao, Keiichi Hatakeyama, Keiichi Ohshima, Ken Yamaguchi and Tohru Mochizuki
    • Organizer
      第72回日本癌学会学術総会
    • Place of Presentation
      神奈川県,パシフィコ横浜
    • Year and Date
      20131000
  • [Presentation] Quantification of splicing variant expression levels in peripheral bloodof patients with gastric cancer2012

    • Author(s)
      Keiichi Hatakeyama, Keiichi Ohshima, Kanako Wakabayashi-Nakao, Yutaka Tanizawa, Masanori Terashima, Ken Yamaguchi and Tohru Mochizuki
    • Organizer
      第71回日本癌学会学術総会
    • Place of Presentation
      北海道,ロイトン札幌,さっぽろ芸文館,札幌市教育文化会館
    • Year and Date
      20120900
  • [Presentation] 癌細胞から放出されるエクソソーム中のプロテオーム解析2012

    • Author(s)
      大島啓一,畠山慶一,中尾香菜子,寺島雅典,山口建,望月徹
    • Organizer
      第71回日本癌学会学術総会
    • Place of Presentation
      北海道,ロイトン札幌,さっぽろ芸文館,札幌市教育文化会館
    • Year and Date
      20120900
  • [Presentation] CEACAM4の甲状腺髄様癌における特異的発現2012

    • Author(s)
      中尾香菜子,畠山慶一,大島啓一,山口建,望月徹
    • Organizer
      第71回日本癌学会学術総会
    • Place of Presentation
      北海道,ロイトン札幌,さっぽろ芸文館,札幌市教育文化会館
    • Year and Date
      20120900
  • [Presentation] 胃癌における新規スプライシングバリアントの臨床病理学的検討2012

    • Author(s)
      山川雄士,谷澤豊,畠山慶一,坂東悦郎,川村泰一,徳永正則,絹笠祐介,上坂克彦,金本秀行,望月徹,寺島雅典
    • Organizer
      第84回日本胃癌学会総会
    • Place of Presentation
      大阪府,大阪国際会議場
    • Year and Date
      20120200
  • [Presentation] Identification of a Novel Protein Isoform Derived from Cancer-related Splicing Variants Using a Proteomics Approach2011

    • Author(s)
      Keiichi Hatakeyama, Keiichi Ohshima, Kanako Wakabayashi-Nakao, Masanori Terashima, Ken Yamaguchi and Tohru Mochizuki
    • Organizer
      第70回日本癌学会学術総会
    • Place of Presentation
      愛知県,名古屋国際会議場
    • Year and Date
      20111000
  • [Presentation] Novel Proteomic Approach for Identification of Protein Isoform Derived from Cancer-related SplicingVariants2011

    • Author(s)
      Keiichi Hatakeyama, Keiichi Ohshima, Kanako Wakabayashi-Nakao, Masanori Terashima, Ken Yamaguchi and Tohru Mochizuki
    • Organizer
      がん若手研究者ワークショップ文部科学省科学研究費新学術領域研究「がん研究分野の特性等を踏まえた支援活動」
    • Place of Presentation
      長野県,アートランドホテル蓼科
    • Year and Date
      20110900
  • [Presentation] がん関連スプライシングバリアント由来の新規プロテインアイソフォームの同定に向けた新規プロテオーム解析2011

    • Author(s)
      畠山慶一,大島啓一,中尾香菜子,寺島雅典,山口建,望月徹
    • Organizer
      日本プロテオーム学会2011年大会
    • Place of Presentation
      新潟県,朱鷺メッセ
    • Year and Date
      20110700
  • [Patent(Industrial Property Rights)] CEACAM5遺伝子のスプライシングバリアント2013

    • Inventor(s)
      中尾香菜子,望月徹,畠山慶一
    • Industrial Property Rights Holder
      静岡県
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      特願 2013-35758
    • Filing Date
      2013-02-26
  • [Patent(Industrial Property Rights)] 甲状腺髄様がん判定方法2013

    • Inventor(s)
      中尾香菜子,望月徹,畠山慶一
    • Industrial Property Rights Holder
      静岡県
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      特許公開2013-255485
    • Acquisition Date
      2013-12-26
  • [Patent(Industrial Property Rights)] スプライスバリアント2013

    • Inventor(s)
      望月徹,畠山慶一
    • Industrial Property Rights Holder
      静岡県
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      特許公開2013-39111
    • Acquisition Date
      2013-02-28
  • [Patent(Industrial Property Rights)] ホルマリン固定パラフィン包埋組織切片中の蛋白質の賦活化処理システム及び賦活化処理方法2011

    • Inventor(s)
      青木豊,海野ゆかり,佐藤孝明,林勇,畠山慶一,小倉俊一郎
    • Industrial Property Rights Holder
      静岡県,島津製作所
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      特願 2011-117334
    • Filing Date
      2011-05-25

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Published: 2015-06-25  

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